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Atherosclerosis map (BIO 482)

Name the atherosclerosis steps in order for Dr. Gabriele's class
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TheSaxyMan
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Last updated: March 31, 2021
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First submittedMarch 31, 2021
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Hint
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1
endothelial cell dysfunction
2
increased permeability to LDLs and adherence of WBCs
3
altered epithelium produces free radicals that oxidize LDLs that accumulate in the intima
4
monocytes invade intima and phagocytose oxidized LDLs forming foam cells
Hint
Answer
5
foam cells and infiltrated T-lymphocytes form fatty streak which later develops into fibrofatty plaque
6
endothelial cells secrete PDGF that stimulate migration of smooth muscle from the media to the intima
7
smooth muscle cells occupying the intima produce a large amount of proteoglycans and collagen that increase the thickness of the intima
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