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Conditions
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#
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Challenge
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Curse of darkness
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1
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Pitch Black
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Toilet themed
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2
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High Brow
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Soy milk + tiny planet
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3
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Head Trauma
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Eve with a bunch of devil items
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4
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Darkness Falls
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Tons of health but really slow
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5
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The Tank
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Blindfolded with orbiting flies to do damage
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6
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Solar System
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My reflection + Ipecac
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7
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Suicide King
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Guppy blindfolded with hairball to do damage
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8
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Cat Got Your Tongue
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Dr. Fetus and Remote Detonator
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9
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Demo Man
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All doors are Curse room doors and deal 1/2 heart of damage
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10
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Cursed!
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Epic Fetus and Loki's horns
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11
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Glass Cannon
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Lemon Mishap and items to make it charge faster
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12
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When Life Gives You Lemons
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Blindfolded with The Bean to do damage
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13
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Beans!
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Deck of cards and things to make it charge faster
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14
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It's in the Cards
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Polyphemus + Cupid's Arrow + My Reflection
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15
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Slow Roll
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Tech 1 and 2, homing shots
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16
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Computer Savvy
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Anti-Gravity + Strange Attractor
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17
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Waka Waka
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The Mulligan + Spider Baby
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18
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The Host
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Blindfolded with a couple of familiars
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19
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The Family Man
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No treasure rooms or starting items
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20
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Purist
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All floors are the same size as chapter 4 XL
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21
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XXXXXXXXL
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16 minute time limit, everything is sped up
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22
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SPEED!
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Kamikaze + Pyromaniac, but you start as ???
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23
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Blue Bomber
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All doors cost 1 cent to go through, at 0 cents you are instantly killed
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24
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PAY TO PLAY
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Start with 12 empty heart containers and Charm of the Vampire
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25
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Have a Heart
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Start with Mom's knife and key pieces, beat Mega Satan
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26
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I RULE!
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Blindfolded with 3 Bob's Brains
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27
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BRAINS!
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Rainbow everything (Rainbow tears, Rainbow baby...)
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28
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PRIDE DAY!
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Missing a shot deals 1/2 heart damage, start with Chocolate Milk
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29
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Onan's Streak
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Punching Bag and Isaac's Heart, defend it with Spear of Destiny and Holy Grail.
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30
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The Guardian
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Start at Mega Satan, go backwards
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31
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Backasswards
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Random pickups/items to sprite, every boss is the Bloat
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32
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Aprils Fool
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Friendly ball gives you charmed enemies
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33
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Pokey mans
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No hearts will ever drop, every curse applied constantly
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34
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Ultra Hard
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Massive damage, massive tear delay
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35
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Pong
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