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NF-2 Diagnostic Criteria

Name all 7 diagnostic criteria for NF-2. according to https://www.msdmanuals.com/professional/multimedia/table/diagnosing-neurofibromatosis
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replycodexomega
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Last updated: June 29, 2025
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First submittedJune 29, 2025
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Pathognomonic
Bilateral vestibular schwannomas
NF2 pathogenic variant in 2 or more related tumors
Major Criteria (need 2 for diagnosis)
2+ meningiomas
diagnosed parent
Unilateral vestibular schwannoma
NF2 pathogenic variant in unaffected tissue
Minor Criteria (need 1 major + 2 minor for diagnosis)
juvenile cataract
retinal hamartoma
epiretinal membrane
nonvestibular schwannoma
meningioma
ependymoma
genetic changes
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