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Unlock Method
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Achievement
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Eve
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The Curdled
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Samson
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The Savage
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Azazel
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The Beknighted
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Lazarus
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The Enigma
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Eden
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The Capricious
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Use the Red Key or Cracked Key to unlock the secret closet in Home as The Lost
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The Baleful
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Lilith
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The Harlot
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Keeper
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The Miser
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Apollyon
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The Empty
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Use the Red Key or Cracked Key to unlock the secret closet in Home as The Forgotten
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The Fettered
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Bethany
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The Zealot
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Use the Red Key or Cracked Key to unlock the secret closet in Home as Jacob and Esau
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The Deserter
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Defeat The Beast as Tainted Isaac
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Glitched Crown
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Defeat The Beast as Tainted Magdalene
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Belly Jelly
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Defeat The Beast as Tainted Cain
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Blue Key
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Defeat The Beast as Tainted Judas
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Sanguine Bond
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Defeat The Beast as Tainted ???
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The Swarm
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Defeat The Beast as Tainted Eve
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Heartbreak
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Defeat The Beast as Tainted Samson
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Larynx
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Defeat The Beast as Tainted Azazel
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Azazel's Rage
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Defeat The Beast as Tainted Lazarus
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Salvation
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Defeat The Beast as Tainted Eden
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TMTRAINER
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Defeat The Beast as Tainted Lost
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Sacred Orb
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Defeat The Beast as Tainted Lilith
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Twisted Pair
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Defeat The Beast as Tainted Keeper
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Strawman
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Defeat The Beast as Tainted Apollyon
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Echo Chamber
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Defeat The Beast as Tainted Forgotten
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Isaac's Tomb
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Defeat The Beast as Tainted Bethany
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Vengeful Spirit
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Defeat The Beast as Tainted Jacob
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Esau Jr.
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Unlock Bethany, Blood Bag, and It Lives!
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Bloody Mary
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Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith
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Baptism by Fire
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Defeat Mother
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Isaac's Awakening
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Defeat Mother
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Seeing Double
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Defeat Mom's Heart 11 times and unlock Marbles
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Pica Run
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Unlock Tainted Forgotten
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Hot Potato
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Unlock Tainted Cain
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Cantripped!
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Unlock Tainted Jacob
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Red Redemption
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Unlock Tainted Eden
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DELETE THIS
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Complete Scat Man (Challenge #36)
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Dirty Mind
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Complete Bloody Mary (Challenge #37)
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Sigil of Baphomet
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Complete Baptism by Fire (Challenge #38)
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Purgatory
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Complete Isaac's Awakening (Challenge #39)
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Spirit Sword
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Complete Seeing Double (Challenge #40)
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Broken Glasses
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Complete Pica Run (Challenge #41)
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Ice Cube
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Donate to Battery Bums until they pay out with an item 5 times
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Charged Penny
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Defeat Ultra Greedier as Tainted Lost
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The Fool?
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Defeat Ultra Greedier as Tainted Judas
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The Magician?
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Defeat Ultra Greedier as Tainted Lilith
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The High Priestess?
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Defeat Ultra Greedier as Tainted Eve
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The Empress?
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Defeat Ultra Greedier as Tainted ???
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The Emperor?
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Defeat Ultra Greedier as Tainted Bethany
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The Hierophant?
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Defeat Ultra Greedier as Tainted Magdalene
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The Lovers?
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Complete Hot Potato (Challenge #42)
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The Chariot?
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Complete Cantripped! (Challenge #43)
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Justice?
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Complete Red Redemption (Challenge #44)
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The Hermit?
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Defeat Ultra Greedier as Tainted Cain
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Wheel of Fortune?
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Defeat Ultra Greedier as Tainted Samson
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Strength?
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Defeat Ultra Greedier as Tainted Keeper
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The Hanged Man?
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Defeat Ultra Greedier as Tainted Forgotten
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Death?
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Complete DELETE THIS (Challenge #45)
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Temperance?
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Defeat Ultra Greedier as Tainted Azazel
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The Devil?
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Defeat Ultra Greedier as Tainted Apollyon
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The Tower?
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Defeat Ultra Greedier as Tainted Isaac
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The Stars?
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Defeat Ultra Greedier as Tainted Jacob
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The Sun?
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Defeat Ultra Greedier as Tainted Jacob
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The Moon?
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Defeat Ultra Greedier as Tainted Lazarus
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Judgement?
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Defeat Ultra Greedier as Tainted Eden
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The World?
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Destroy 10 Battery Bums
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Old Capacitor
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After destroying Hornfel's minecart, kill him before he escapes
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Brimstone Bombs
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Earn all Hard mode Completion Marks for all non-Tainted characters)
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Mega Mush
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Isaac
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Mom's Lock
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Defeat Mother as Tainted Isaac
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Dice Bag
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Magdalene
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Holy Crown
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Defeat Mother as Tainted Magdalene
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Mother's Kiss
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Cain
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Gilded Key
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Defeat Mother as Tainted Cain
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Lucky Sack
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Judas
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Your Soul
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Defeat Mother as Tainted Judas
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Number Magnet
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Defeat Isaac, Satan, ???, and The Lamb as Tainted ???
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Dingle Berry
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Defeat Mother as Tainted ???
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Ring Cap
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Eve
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Strange Key
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Defeat Mother as Tainted Eve
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Lil Clot
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Samson
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Temporary Tattoo
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Defeat Mother as Tainted Samson
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Swallowed M80
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Azazel
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Wicked Crown
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Defeat Mother as Tainted Azazel
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Azazel's Stump
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Lazarus
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Torn Pocket
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Defeat Mother as Tainted Lazarus
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Torn Card
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Eden
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Nuh Uh!
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Defeat Mother as Tainted Eden
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Modeling Clay
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Lost
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Kid's Drawing
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Defeat Mother as Tainted Lost
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Crystal Key
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Lilith
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The Twins
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Defeat Mother as Tainted Lilith
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Adoption Papers
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Defeat Isaac, Satan, ???, and Blue Baby as Tainted Keeper
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Keeper's Bargain
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Defeat Mother as Tainted Keeper
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Cursed Penny
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Apollyon
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Cricket Leg
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Defeat Mother as Tainted Apollyon
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Apollyon's Best Friend
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Forgotten
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Polished Bone
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Defeat Mother as Tainted Forgotten
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Hollow Heart
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Bethany
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Expansion Pack
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Defeat Mother as Tainted Bethany
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Beth's Essence
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Defeat Isaac, Satan, ???, and The Lamb as Tainted Jacob
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RC Remote
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Defeat Mother as Tainted Jacob
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Found Soul
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Spend 40+ coins in a single Shop
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Member Card
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Defeat Delirium as Tainted Isaac
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Spindown Dice
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Defeat Delirium as Tainted Magdalene
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Hypercoagulation
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Defeat Delirium as Tainted Cain
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Bag of Crafting
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Defeat Delirium as Tainted Judas
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Dark Arts
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Defeat Delirium as Tainted ???
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IBS
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Defeat Delirium as Tainted Eve
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Sumptorium
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Defeat Delirium as Tainted Samson
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Berserk!
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Defeat Delirium as Tainted Azazel
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Hemoptysis
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Defeat Delirium as Tainted Lazarus
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Flip
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Defeat Delirium as Tainted Eden
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Corrupted Data
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Defeat Delirium as Tainted Lost
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Ghost Bombs
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Defeat Delirium as Tainted Lilith
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Gello
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Defeat Delirium as Tainted Keeper
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Keeper's Kin
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Defeat Delirium as Tainted Apollyon
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Abyss
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Defeat Delirium as Tainted Forgotten
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Decap Attack
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Defeat Delirium as Tainted Bethany
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Lemegeton
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Defeat Delirium as Tainted Jacob
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Anima Sola
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Defeat Mega Satan as Tainted Isaac
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Mega Chest
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Defeat Mega Satan as Tainted Magdalene
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Queen of Hearts
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Defeat Mega Satan as Tainted Cain
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Gold Pill
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Defeat Mega Satan as Tainted Judas
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Black Sack
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Defeat Mega Satan as Tainted ???
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Charming Poop
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Defeat Mega Satan as Tainted Eve
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Horse Pill
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Defeat Mega Satan as Tainted Samson
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Crane Game
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Defeat Mega Satan as Tainted Azazel
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Hell Game
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Defeat Mega Satan as Tainted Lazarus
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Wooden Chest
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Defeat Mega Satan as Tainted Eden
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Wild Card
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Defeat Mega Satan as Tainted Lost
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Haunted Chest
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Defeat Mega Satan as Tainted Lilith
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Fool's Gold
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Defeat Mega Satan as Tainted Keeper
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Golden Penny
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Defeat Mega Satan as Tainted Apollyon
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Rotten Beggar
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Defeat Mega Satan as Tainted Forgotten
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Golden Battery
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Defeat Mega Satan as Tainted Bethany
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Confessional
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Defeat Mega Satan as Tainted Jacob
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Golden Trinkets
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Complete Boss Rush and defeat Hush as Tainted Isaac
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Soul of Isaac
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Complete Boss Rush and defeat Hush as Tainted Magdalene
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Soul of Magdalene
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Complete Boss Rush and defeat Hush as Tainted Cain
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Soul of Cain
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Complete Boss Rush and defeat Hush as Tainted Judas
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Soul of Judas
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Complete Boss Rush and defeat Hush as Tainted ???
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Soul of ???
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Complete Boss Rush and defeat Hush as Tainted Eve
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Soul of Eve
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Complete Boss Rush and defeat Hush as Tainted Samson
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Soul of Samson
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Complete Boss Rush and defeat Hush as Tainted Azazel
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Soul of Azazel
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Complete Boss Rush and defeat Hush as Tainted Lazarus
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Soul of Lazarus
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Complete Boss Rush and defeat Hush as Tainted Eden
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Soul of Eden
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Complete Boss Rush and defeat Hush as Tainted Lost
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Soul of The Lost
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Complete Boss Rush and defeat Hush as Tainted Keeper
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Soul of the Keeper
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Complete Boss Rush and defeat Hush as Tainted Lilith
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Soul of Lilith
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Complete Boss Rush and defeat Hush as Tainted Apollyon
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Soul of Apollyon
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Complete Boss Rush and defeat Hush as Tainted Forgotten
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Soul of The Forgotten
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Complete Boss Rush and defeat Hush as Tainted Bethany
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Soul of Bethany
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Complete Boss Rush and defeat Hush as Tainted Jacob
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Soul of Jacob and Esau
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Defeat Mother
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A Strange Door
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Earn all Hard mode Completion Marks for all characters
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Death Certificate
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Unlock every other achievement and pick up every item in the game (Repentance)
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Dead God
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