Effects after damage in The Binding of Isaac Repentance+

Items and trinkets that activate upon having Isaac take damage (or have an effect that activates upon taking damage, such as losing the effect) even if just randomly or under specific conditions. Items that activate only by being low on health don't count unless they specifically require taking damage (Effect per room).
Items that need you to absorb/hold other items don't count (Ex. Void).
Active items that charge by getting hit on their own or damage Isaac TO activate are counted.
Converting hearts is not the same as taking damage. Similarly, getting hurt by the effect is not the same as taking damage to activate.
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TraceyMailin
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Last updated: January 20, 2025
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First submittedJanuary 20, 2025
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Average score33.3%
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Type
Answer
Passive
Dead Bird
Active
Razor Blade
Active
IV Bag
Passive
Habit
Passive
Bloody Lust
Passive
Celtic Cross
Passive
The Black Bean
Active
Blood Rights
Passive
Fanny Pack
Passive
Sharp Plug
Passive
Anemic
Passive
Gimpy
Passive
Piggy Bank
Passive
Missing Page 2
Passive
Smart Fly
Passive
Best Bud
Passive
Cancer
Passive
Virgo
Passive
Cursed Eye
Passive
The Polaroid
Passive
The Negative
Active
Glass Cannon
Passive
Curse of the Tower
Passive
Zodiac
Passive
Purity
Passive
Cambion Conception
Passive
Crown Of Light
Passive
Shard of Glass
Passive
Varicose Veins
Active
Metronome
Passive
Bozo
Passive
Leprosy
Passive
Marbles
Passive
Mystery Egg
Passive
Hallowed Ground
Passive
Brittle Bones
Passive
It Hurts
Passive
Paschal Candle
Passive
Blood Oath
Passive
The Intruder
Passive*
Damocles
Passive
Bird Cage
Active
Larynx
Passive
Blood Bombs
Passive
Giant Cell
Passive
Cracked Orb
Passive
Astral Projection
Passive
Heartbreak
Passive
Bloody Gust
Passive
Salvation
Passive
Vengeful Spirit
Passive
Hypercoagulation
Trinket
Swallowed Penny
Trinket
Cartridge
Trinket
Monkey Paw
Trinket
Mysterious Paper
Trinket
Umbilical Cord
Trinket
Red Patch
Trinket
Cursed Skull
Trinket
A Missing Page
Trinket
Cracked Dice
Trinket
Error
Trinket
Tonsil
Trinket
Wish Bone
Trinket
Bag Lunch
Trinket
Perfection
Trinket
Torn Pocket
Trinket
Modeling Clay
Trinket
Swallowed M80
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1 Comments
+1
Level 32
Nov 13, 2025
Shouldn't Large Zit and Scapular be on here?