| Hint | Answer | % Correct |
|---|---|---|
| How many weeks into embryological developement do the limb buds arise? | 4 | 83%
|
| By what weel in developement will this start? | 6 | 67%
|
| By what week have digits in a healthy individual seperated? | 8 | 67%
|
| Achondroplasia is a disease caused by mutation in the FGF3 receptor, but what is another more colloquial term for it? | Dwarfism | 67%
|
| What type of cells do osteoprogenitor cells differentiate to become? | Osteoblasts | 67%
|
| What hormone is responsible for cranial caudal pattterning of the hand? | Sonic Hedgehog | 50%
|
| Polydactyly is the presence of additional digits and is one of the most common congenital disorders of the upper limb, what is its prevalence? Write in form 1 in 3000 etc. | 1 in 500 to 1000 | 33%
|
| The process of cartillage turning into bones is referred to as? | Endochondrial Ossification | 33%
|
| What paterning is the Apical Ectodermal ridge involved in? | Proximal-distal | 33%
|
| What specific gene/transcription factor denotes where the limb buds form? | Tbx5 | 33%
|
| What drug is known to have caused phocomelia? | Thalidomide | 33%
|
| What chemical does it emit to enable this? | FGF8 | 17%
|
| The upper limb bud is the first to arise, but where does it derive from? | Lateral Plate Mesoderm | 17%
|
| The area that produces this hormone is referred to as? | Zone of Polarizing Activity | 17%
|
| What does the center of the limb bud consist of? | Mesenchyme | 0%
|
| Cleidocranial dysplasia is a condition where patients have underdeveloped/no clavicles, what gene is typically associated with it. | Runx2 | 0%
|