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Sentinel cells - Statistics

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  • This quiz has been taken 3 times
  • The average score is 8 of 15
Answer Stats
Hint Answer % Correct
How many functional TLR genes do humans have? 10
100%
What cytokine is a major example of this and also induces the acute phase response? IL-6
100%
What is another example of one, that increases vascular permeability, but if systemically released may acumulate to shock? TNF-alpha
100%
Two downstream molecules are normally activate when TLRs are NF kappaB is one whats the other? AP-1
50%
Sentinel cells play a major role in sensing damage and infection, there are three key one, mast cells, macrophages and what third? Dendritic
50%
What is the group name given to cytokines that induce fever? Endogenous pyrogens
50%
Odd numbered TLRs are not found on the cell surface, so where are they found? Endosomes
50%
What specific type of bacteria is this ligand found in the membrane of? Gram negative
50%
Sometimes the cytosolic receptors link together to form a polymer, which can be used to activate caspase 1 which then activates IL-1beta, what is the name of the polymer? Inflammasome
50%
One specific PRR is Toll Like Receptor 4, what is the specific ligand that it recognises? LPS
50%
Finally which recognise cytosolic molecules? NOD-like receptors
50%
They express pattern recognition receptors to recognise what molecules? PAMPs/DAMPs
50%
And which are important in viral infections? RIG-I-Like receptors
50%
NOD2 is a type of PRR what disease is associated with mutations in it? Crohn's
0%
There are other families of PRR, which are important in fungal infections? C-type Lectin receptors
0%
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