Glycolysis/Gluconeogenesis Pathway

Pathway for glycolysis and gluconeogenesis including enzymes.
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Last updated: December 5, 2024
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First submittedDecember 5, 2024
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Glycolysis Molecule
#
Molecule
1
1
Glucose
2
1
Glucose 6-Phosphate
3
1
Fructose 6-Phosphate
4
1
Fructose 1,6-Bisphosphate
5
1
Dihydroxyacetone Phosphate
5
2
Glyceraldehyde 3-Phosphate
6
2
1,3-Bisphosphoglycerate
7
2
3-Phosphoglycerate
8
2
2-Phosphoglycerate
9
2
Phosphoenolpyruvate
10
2
Pyruvate
Step
Glycolysis enzyme
Cofactor
1
Hexokinase
ATP to ADP
2
Phosphohexose isomerase
none
3
Phosphofructokinase-1
ATP to ADP
4
Aldolase
none
5
Triose Phosphate Isomerase
none
6
Glyceraldehyde 3-Phosphate Dehydrogenase
2Pi, 2NAD+ to 2NADH, 2H+
7
Phosphoglycerate Kinase
2ADP to 2ATP
8
Phosphoglycerate mutase
none
9
Enolase
none
10
Pyruvate kinase
2ADP to 2ATP
Gluconeogenesis Molecule
#
Molecule
1
2
Pyruvate
2
2
Oxaloacetate
3
2
Phosphoenolpyruvate
4
2
2-Phosphoglycerate
5
2
3-Phosphoglycerate
6
2
1,3-Bisphosphoglycerate
7
2
Glyceraldehyde 3-Phosphate
7
1
Dihydroxyacetone Phosphate
8
1
Fructose 1,6-Bisphosphate
9
1
Fructose 6-Phosphate
10
1
Glucose 6-Phosphate
11
1
Glucose
Step
Gluconeogenesis Enzyme
Cofactor
1
Pyruvate carboxylase
2ATP to 2ADP
2
PEP carboxykinase
2GTP to 2GDP
3
Enolase
none
4
Phosphoglycerate mutase
none
5
Phosphoglycerate Kinase
2ATP to 2ADP
6
Glyceraldehyde 3-Phosphate Dehydrogenase
2NADH, 2H+ to 2Pi, 2NAD+
7
Triose Phosphate Isomerase
none
8
Aldolase
none
9
Fructose 1,6-Bisphosphatase-1
H2O to Pi
10
Phosphohexose isomerase
none
11
Glucose 6-Phosphatase
H2O to Pi
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