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key pharmacology equations

use brackets, * for multiply and / for divide square brackets for concentration of
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alanaevans
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Last updated: December 4, 2024
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First submittedDecember 3, 2024
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Average score14.3%
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equation
Answer
Kd =
([d][r])/[dr]
p (fractional occupancy) =
[d]/([d] + Kd)
gaddum-schild: concentration ratio =
1 + [b]/Kb
half life in dissociation assays =
0.693/Koff
Kon =
(Kobs - Koff)/[l]
half life in association assays =
0.693/Kobs
cheng-prusoff: Ki =
IC50/(1+[l]/Kd)
Hint
Answer
rate of elimination =
clearance*Cp
Cp =
amount of drug/Vd
half life (ADME) =
(0.693*Vd)/clearance
rate of infusion =
Css*clearance
Css (average) =
(dose*oral bioavailability)/(time between doses*clearance)
henderson-hasselbalch for weak acids
pH = pKa + log[A-]/[HA]
henderson-hasselbalch for weak bases
pH = pKa + log [HA]/A-]
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