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Other Important Concepts in Hema

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yannnnn
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Last updated: November 10, 2025
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First submittedNovember 10, 2025
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Low Prevalence Antigen
Wright’s antigen
Swann (Swa)
Mta
Tr
 
High Prevalence Antigen
Augustine (Ata)
Crome (Cra)
Ena
Gerbich
Gregory (Gya)
Holley (Hy)
Jacobs (Jra)
Joseph (Joa)
Langereis (Lan)
Vel (Ve)
 
HPA Common in Blacks
Augustine
Cromer
Joseph
 
High titer, low avidity
anti-Ch/Rg
anti-Kn
anti-Yk (york)
anti-Cs (cost)
anti-JMH
anti-McCoy
 
Additional Serum Procedures in Antibody Identification
Hemagglutinin inhibition
Serum adsorption
Use of sulfhydryl reagents
Titration
Prewarming
Saline Replacement
 
Additional Red Cell Procedures in Antibody Identification
Enzyme Treatment
Use of AET/DTT
Elution
Chloroquine diphosphate
Use of ZZAP
Lectin Typing
Cell Separation Technique
 
Donation Process
Donor registration
Interview and physical exam
Donor selection and blood collection
2 weeks Referral Due to Vaccination
Typhoid
Oral Polio
Measles
Mumps
Yellow Fever
 
Medications that Can Cause Birth Defects
Propecia
Proscar
Accutane
Avodart
Soriatane
 
Antiplatelet Agent
Feldene
Brilinta
Ticlid
Effient
Plavix
Zontivity
 
Erythrocytapheresis indications
Sickle cell disease
Malaria
Babesiosis
Incompatible RBCs
 
RBC Storage: Decrease
Viable cells
Glucose
ATP
pH
2,3-DPG
 
RBC Storage: Increase
Lactic acid
Plasma K+
Plasma hemoglobin
 
RBC Storage: Shift to the left
Oxygen dissociation curve
 
Component of rejuvenation solution
Phosphate
Inosine
Glucose
Pyruvate
Adenosine
Penetrating agents
Glycerol
Dimethylsulfoxide
 
Non-Penetrating agents
Glucose
Hydroxyethyl starch
Polyvinylpyrrolidone
 
Platelet Storage Increase
Lactate
Degranulation (B-thromboglobulin, platelet factor 4)
Platelet activation markers (P-selectin [CD62P] or CD63]
 
Platelet Storage Decrease
pH
ATP
Morphology
Platelet aggregation
 
Component of Cryoprecipitate
80 U AHF/Factor VIII
150-250 mg fibrinogen
VwF
Factor XIII
Fibronectin
 
CPP contains
albumin
II
V
VII
IX
X
X
XI
ADAMTS13
 
CPP is deficient in
I
VIII
XIII
vWF
cryoglobulin
fibronectin
 
CPP cannot be used as a substitute for
FFP
PF24
thawed plasma
Criteria to be Eligible for Computer Crossmatch
no current or past history of clinically significant antibodies
at least 2 concordant ABO typing results
 
IUT Unit Requirements
fresh <7 days old
leukoreduced
irradiated
Hgb-S negative
CMV-negative
Ag-negative for maternal RBC antibodies
Group O D-negative
 
Solutions Avoided for Dilution of Blood Components
5% dextrose solution in water
Ringers solution
 
Immmediate Transfusion Reactions
AHTR
FNHTR
Allergic or urticarial
Anaphylactic or anaphylactoid
TRALI
TACO
Bacterial contamination or sepsis
Transfusion-related adverse events during massive transfusion and physical or chemical during transfusion
 
Delayed Transfusion Reactions
DHTR
TA-GVHD
PTP
Iron overload or transfusion-induced hemosiderosis
 
Immediate Immunulogic TR
AHTR
FNHTR
Allergic
Anaphylactic
TRALI
 
Immediate Non-Immunulogic TR
TACO
Bacterial contamination
 
Delayed Immunologic TR
PTP
TA-GVHD
DHTR
 
Delayed Non-Immunologic TR
Transfusion-induced hemosiderosis
Disease transmission
Population at risk of Hemosiderosis
Sickle cell anemia
Hemoglobinopathies
Thalassemia
Patient who are transfusion dependent
 
Population at risk of TA-GVHD
Immunocompromised
Immunodeficient
Cancer
Infants
 
Prevention and Treatment of Hemosiderosis
Deferroxamine
Desferioxamine
Neocytes
 
What to do during transfusion reaction?
Stop the transfusion
Keep IV open with saline
Perform clerical check for ID errors
Contact treating physician
Monitor or record vital signs
 
Parasites that can be Transmitted through Transfusion
Babesia
Leishmania
Microfilaria
Plasmodium
Toxoplasma
Trypanosoma
 
Blood Systems Causing HDFN
Anti-D
Anti-DC
Anti-DE
Anti-c
Anti-Kell
Anti-Duffy
Anti-Kidd
ABO
 
Conditions where IUT is necessary
MCA-PSV (>1.5 MoM)
Fetal hydrops
Cord blood sample <10 g/dL
Amniotic fluid OD 450 nm high
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