| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 9 | Josef Martínez | ST | 214 | 130 (21) | 2017-2025 | 83%
| ||
| 1 | Landon Donovan | ST | 340 | 145 (109) | 2001-2014, 2016-2017 | 83%
| ||
| 10 | Bradley Wright-Phillips | ST | 231 | 114 (28) | 2013-2021 | 67%
| ||
| 21 | Carlos Vela | RW | 152 | 78 (42) | 2018-2023 | 67%
| ||
| 31 | Clint Dempsey | CF | 186 | 72 (35) | 2004-2006, 2013-2018 | 67%
| ||
| 24 | Robbie Keane | ST | 125 | 83 (34) | 2011-2016 | 67%
| ||
| 38 | Jozy Altidore | ST | 202 | 79 (24) | 2006-2008, 2015-2023 | 50%
| ||
| 2 | Chris Wondolowski | ST | 410 | 169 (41) | 2005-2021 | 33%
| ||
| 13 | Gyasi Zardes | ST | 325 | 103 (32) | 2013-2024 | 33%
| ||
| 14 | Hany Mukhtar | AM | 179 | 82 (48) | 2020-2025 | 33%
| ||
| 3 | Kei Kamara | ST | 461 | 146 (50) | 2006-2013, 2015-2020, 2022-2025 | 33%
| ||
| 30 | Sebastian Giovinco | CF | 114 | 68 (41) | 2015-2018 | 33%
| ||
| 6 | Dwayne de Rosario | AM | 342 | 104 (56) | 2001-2014 | 17%
| ||
| 7 | Luciano Acosta | AM | 272 | 77 (75) | 2016-2019, 2021-2025 | 17%
| ||
| 23 | Albert Rusnák | AM | 263 | 69 (50) | 2017-2025 | 0%
| ||
| 19 | Ante Razov | ST | 196 | 89 (35) | 2000-2008 | 0%
| ||
| 5 | Brad Davis | LM | 392 | 57 (103) | 2002-2016 | 0%
| ||
| 26 | Brian Ching | ST | 233 | 82 (32) | 2001-2002, 2003-2013 | 0%
| ||
| 37 | Carles Gil | AM | 191 | 49 (55) | 2019-2025 | 0%
| ||
| 33 | Carlos Ruiz | ST | 183 | 89 (17) | 2002-2008, 2011-2012, 2013-2014, 2016-2017 | 0%
| ||
| 18 | C.J. Sapong | ST | 367 | 89 (35) | 2011-2023 | 0%
| ||
| 11 | Diego Fagúndez | LW | 422 | 79 (62) | 2011-2025 | 0%
| ||
| 35 | Diego Rossi | AM | 174 | 74 (31) | 2018-2021, 2023-2025 | 0%
| ||
| 8 | Diego Váleri | AM | 259 | 85 (67) | 2013-2021 | 0%
| ||
| 36 | Dom Dwyer | ST | 229 | 86 (19) | 2012-2019, 2021-2022 | 0%
| ||
| 44 | Edgar Espíndola | ST | 212 | 64 (36) | 2007-2016 | 0%
| ||
| 20 | Edson Buddle | ST | 304 | 100 (21) | 2001-2010, 2012-2015 | 0%
| ||
| 41 | Ethan Finlay | RW | 333 | 58 (43) | 2012-2024 | 0%
| ||
| 28 | Federico Higuaín | AM | 229 | 58 (52) | 2012-2021 | 0%
| ||
| 15 | Fredy Montero | ST | 272 | 85 (42) | 2009-2012, 2017-2018, 2019-2023 | 0%
| ||
| 12 | Jaime Moreno | ST | 255 | 88 (48) | 2000-2010 | 0%
| ||
| 17 | Javier Morales | AM | 255 | 51 (73) | 2007-2017 | 0%
| ||
| 4 | Jeff Cunningham | ST | 312 | 114 (49) | 2000-2011 | 0%
| ||
| 42 | Josh Wolff | RW | 225 | 62 (39) | 2000-2006, 2008-2012 | 0%
| ||
| 29 | Justin Meram | LW | 356 | 55 (54) | 2011-2023 | 0%
| ||
| 40 | Maximiliano Urruti | ST | 312 | 72 (30) | 2013-2023, 2025-2026 | 0%
| ||
| 39 | Michael Barrios | RW | 272 | 44 (58) | 2015-2023 | 0%
| ||
| 43 | Nicolás Lodeiro | AM | 238 | 42 (58) | 2016-2025 | 0%
| ||
| 27 | Sacha Kljestan | AM | 329 | 44 (67) | 2006-2010, 2015-2022 | 0%
| ||
| 34 | Sébastien Le Toux | ST | 263 | 59 (46) | 2009-2017 | 0%
| ||
| 22 | Steve Ralston | RM | 256 | 54 (65) | 2000-2009 | 0%
| ||
| 16 | Taylor Twellman | ST | 174 | 101 (25) | 2002-2009 | 0%
| ||
| 32 | Teal Bunbury | ST | 413 | 75 (32) | 2010-2025 | 0%
| ||
| 25 | Will Bruin | ST | 328 | 80 (34) | 2011-2023 | 0%
|