| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 2 | Kei Kamara | ST | 461 | 146 (50) | 2006-2013, 2015-2020, 2022-2025 | 75%
| ||
| 3 | Landon Donovan | ST | 340 | 145 (109) | 2001-2014, 2016-2017 | 75%
| ||
| 6 | Bradley Wright-Phillips | ST | 231 | 114 (28) | 2013-2021 | 50%
| ||
| 1 | Chris Wondolowski | ST | 410 | 169 (41) | 2005-2021 | 50%
| ||
| 7 | Dwayne de Rosario | AM | 342 | 104 (56) | 2001-2014 | 50%
| ||
| 4 | Josef Martínez | ST | 214 | 130 (21) | 2017-2025 | 50%
| ||
| 10 | Edson Buddle | ST | 304 | 100 (21) | 2001-2010, 2012-2015 | 25%
| ||
| 8 | Gyasi Zardes | ST | 325 | 103 (32) | 2013-2024 | 25%
| ||
| 5 | Jeff Cunningham | ST | 312 | 114 (49) | 2000-2011 | 25%
| ||
| 9 | Taylor Twellman | ST | 174 | 101 (25) | 2002-2009 | 25%
|