| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 1 | Landon Donovan | ST | 340 | 145 (109) | 2001-2014, 2016-2017 | 100%
| ||
| 9 | Josef Martínez | ST | 214 | 130 (21) | 2017-2025 | 33%
| ||
| 3 | Kei Kamara | ST | 461 | 146 (50) | 2006-2013, 2015-2020, 2022-2025 | 33%
| ||
| 5 | Brad Davis | LM | 392 | 57 (103) | 2002-2016 | 0%
| ||
| 2 | Chris Wondolowski | ST | 410 | 169 (41) | 2005-2021 | 0%
| ||
| 8 | Diego Váleri | AM | 259 | 85 (67) | 2013-2021 | 0%
| ||
| 6 | Dwayne de Rosario | AM | 342 | 104 (56) | 2001-2014 | 0%
| ||
| 4 | Jeff Cunningham | ST | 312 | 114 (49) | 2000-2011 | 0%
| ||
| 7 | Luciano Acosta | AM | 272 | 77 (75) | 2016-2019, 2021-2025 | 0%
|