| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 19 | Andy Williams | AM | 298 | 29 (52) | 2000-2011 | 100%
| ||
| 1 | Landon Donovan | ST | 340 | 145 (109) | 2001-2014, 2016-2017 | 100%
| ||
| 21 | Albert Rusnák | AM | 263 | 69 (50) | 2017-2025 | 50%
| ||
| 2 | Brad Davis | LM | 392 | 57 (103) | 2002-2016 | 50%
| ||
| 16 | Carles Gil | AM | 191 | 49 (55) | 2019-2025 | 50%
| ||
| 9 | Cristian Espinoza | RW | 215 | 35 (63) | 2019-2025 | 50%
| ||
| 11 | Diego Fagúndez | LW | 422 | 79 (62) | 2011-2025 | 50%
| ||
| 6 | Diego Váleri | AM | 259 | 85 (67) | 2013-2021 | 50%
| ||
| 15 | Dwayne de Rosario | AM | 342 | 104 (56) | 2001-2014 | 50%
| ||
| 18 | Federico Higuaín | AM | 229 | 58 (52) | 2012-2021 | 50%
| ||
| 4 | Javier Morales | AM | 255 | 51 (73) | 2007-2017 | 50%
| ||
| 5 | Julian Gressel | RM | 263 | 27 (68) | 2017-2025 | 50%
| ||
| 14 | Justin Mapp | RM | 307 | 22 (57) | 2002-2016 | 50%
| ||
| 17 | Justin Meram | LW | 356 | 55 (54) | 2011-2023 | 50%
| ||
| 20 | Kei Kamara | ST | 461 | 146 (50) | 2006-2013, 2015-2020, 2022-2025 | 50%
| ||
| 3 | Luciano Acosta | AM | 272 | 77 (75) | 2016-2019, 2021-2025 | 50%
| ||
| 10 | Maxi Moralez | AM | 215 | 30 (63) | 2017-2025 | 50%
| ||
| 12 | Michael Barrios | RW | 272 | 44 (58) | 2015-2023 | 50%
| ||
| 13 | Nicolás Lodeiro | AM | 238 | 42 (58) | 2016-2025 | 50%
| ||
| 7 | Sacha Kljestan | AM | 329 | 44 (67) | 2006-2010, 2015-2022 | 50%
| ||
| 22 | Shea Salinas | LW | 372 | 21 (50) | 2008-2022 | 50%
| ||
| 8 | Steve Ralston | RM | 256 | 54 (65) | 2000-2009 | 50%
|