| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 28 | Federico Higuaín | AM | 229 | 58 (52) | 2012-2021 | 100%
| ||
| 23 | Albert Rusnák | AM | 263 | 69 (50) | 2017-2025 | 50%
| ||
| 5 | Brad Davis | LM | 392 | 57 (103) | 2002-2016 | 50%
| ||
| 10 | Bradley Wright-Phillips | ST | 231 | 114 (28) | 2013-2021 | 50%
| ||
| 26 | Brian Ching | ST | 233 | 82 (32) | 2001-2002, 2003-2013 | 50%
| ||
| 51 | Brian White | ST | 181 | 76 (20) | 2018-2025 | 50%
| ||
| 37 | Carles Gil | AM | 191 | 49 (55) | 2019-2025 | 50%
| ||
| 33 | Carlos Ruiz | ST | 183 | 89 (17) | 2002-2008, 2011-2012, 2013-2014, 2016-2017 | 50%
| ||
| 21 | Carlos Vela | RW | 152 | 78 (42) | 2018-2023 | 50%
| ||
| 57 | Chris Pontius | LW | 259 | 53 (40) | 2009-2019 | 50%
| ||
| 2 | Chris Wondolowski | ST | 410 | 169 (41) | 2005-2021 | 50%
| ||
| 31 | Clint Dempsey | CF | 186 | 72 (35) | 2004-2006, 2013-2018 | 50%
| ||
| 79 | Cristian Arango | ST | 122 | 66 (16) | 2021-2025 | 50%
| ||
| 46 | Cristian Espinoza | RW | 215 | 35 (63) | 2019-2025 | 50%
| ||
| 58 | Dániel Sallói | LW | 240 | 54 (38) | 2017-2025 | 50%
| ||
| 78 | Davy Arnaud | CM | 351 | 50 (32) | 2002-2015 | 50%
| ||
| 64 | Denis Bouanga | LW | 101 | 65 (25) | 2022-2025 | 50%
| ||
| 11 | Diego Fagúndez | LW | 422 | 79 (62) | 2011-2025 | 50%
| ||
| 35 | Diego Rossi | AM | 174 | 74 (31) | 2018-2021, 2023-2025 | 50%
| ||
| 8 | Diego Váleri | AM | 259 | 85 (67) | 2013-2021 | 50%
| ||
| 36 | Dom Dwyer | ST | 229 | 86 (19) | 2012-2019, 2021-2022 | 50%
| ||
| 6 | Dwayne de Rosario | AM | 342 | 104 (56) | 2001-2014 | 50%
| ||
| 41 | Ethan Finlay | RW | 333 | 58 (43) | 2012-2024 | 50%
| ||
| 93 | Graham Zusi | RB | 352 | 30 (46) | 2009-2023 | 50%
| ||
| 13 | Gyasi Zardes | ST | 325 | 103 (32) | 2013-2024 | 50%
| ||
| 14 | Hany Mukhtar | AM | 179 | 82 (48) | 2020-2025 | 50%
| ||
| 54 | Ignacio Piatti | LW | 135 | 66 (29) | 2014-2019 | 50%
| ||
| 82 | Jason Kreis | RW | 180 | 60 (21) | 2000-2007 | 50%
| ||
| 17 | Javier Morales | AM | 255 | 51 (73) | 2007-2017 | 50%
| ||
| 92 | Jeremy Ebobisse | ST | 217 | 61 (17) | 2017-2025 | 50%
| ||
| 66 | Jesús Ferreira | ST | 195 | 57 (31) | 2017-2025 | 50%
| ||
| 68 | Jonathan Osorio | CM | 326 | 52 (35) | 2013-2025 | 50%
| ||
| 50 | Jordan Morris | ST | 210 | 70 (27) | 2016-2017, 2019-2025 | 50%
| ||
| 9 | Josef Martínez | ST | 214 | 130 (21) | 2017-2025 | 50%
| ||
| 42 | Josh Wolff | RW | 225 | 62 (39) | 2000-2006, 2008-2012 | 50%
| ||
| 38 | Jozy Altidore | ST | 202 | 79 (24) | 2006-2008, 2015-2023 | 50%
| ||
| 52 | Julian Gressel | RM | 263 | 27 (68) | 2017-2025 | 50%
| ||
| 29 | Justin Meram | LW | 356 | 55 (54) | 2011-2023 | 50%
| ||
| 3 | Kei Kamara | ST | 461 | 146 (50) | 2006-2013, 2015-2020, 2022-2025 | 50%
| ||
| 95 | Kyle Beckerman | DM | 496 | 41 (34) | 2000-2020 | 50%
| ||
| 1 | Landon Donovan | ST | 340 | 145 (109) | 2001-2014, 2016-2017 | 50%
| ||
| 90 | Lionel Messi | RW | 53 | 50 (28) | 2023-2025 | 50%
| ||
| 7 | Luciano Acosta | AM | 272 | 77 (75) | 2016-2019, 2021-2025 | 50%
| ||
| 47 | Mike Magee | ST | 314 | 70 (28) | 2003-2016 | 50%
| ||
| 45 | Ola Kamara | ST | 173 | 83 (16) | 2016-2022 | 50%
| ||
| 24 | Robbie Keane | ST | 125 | 83 (34) | 2011-2016 | 50%
| ||
| 30 | Sebastian Giovinco | CF | 114 | 68 (41) | 2015-2018 | 50%
| ||
| 34 | Sébastien Le Toux | ST | 263 | 59 (46) | 2009-2017 | 50%
| ||
| 16 | Taylor Twellman | ST | 174 | 101 (25) | 2002-2009 | 50%
| ||
| 77 | Thierry Henry | ST | 122 | 51 (33) | 2010-2014 | 50%
| ||
| 25 | Will Bruin | ST | 328 | 80 (34) | 2011-2023 | 50%
| ||
| 69 | Alan Gordon | ST | 294 | 59 (27) | 2004-2018 | 0%
| ||
| 91 | Alejandro Moreno | ST | 272 | 52 (26) | 2002-2012 | 0%
| ||
| 75 | Álvaro Saborío | ST | 158 | 73 (12) | 2010-2016 | 0%
| ||
| 88 | Amado Guevara | AM | 153 | 41 (37) | 2003-2009 | 0%
| ||
| 80 | Andy Williams | AM | 298 | 29 (52) | 2000-2011 | 0%
| ||
| 19 | Ante Razov | ST | 196 | 89 (35) | 2000-2008 | 0%
| ||
| 76 | Benny Feilhaber | CM | 262 | 40 (44) | 2011-2019 | 0%
| ||
| 94 | Brian Mullan | RM | 322 | 29 (46) | 2001-2013 | 0%
| ||
| 74 | Chad Barrett | ST | 278 | 58 (27) | 2005-2017 | 0%
| ||
| 61 | Chris Klein | RM | 286 | 43 (48) | 2000-2010 | 0%
| ||
| 65 | Chris Rolfe | ST | 239 | 64 (25) | 2005-2009, 2012-2016 | 0%
| ||
| 81 | Christian Gómez | AM | 144 | 48 (33) | 2004-2009 | 0%
| ||
| 18 | C.J. Sapong | ST | 367 | 89 (35) | 2011-2023 | 0%
| ||
| 97 | Clint Mathis | AM | 199 | 49 (26) | 2000-2003, 2005-2010 | 0%
| ||
| 62 | Conor Casey | ST | 195 | 71 (20) | 2007-2016 | 0%
| ||
| 71 | Dániel Gazdag | AM | 151 | 63 (23) | 2021-2025 | 0%
| ||
| 48 | David Villa | ST | 117 | 77 (21) | 2015-2018 | 0%
| ||
| 59 | Diego Rubio | ST | 220 | 59 (33) | 2016-2025 | 0%
| ||
| 56 | Djordje Mihailovic | AM | 195 | 44 (49) | 2017-2022, 2024-2025 | 0%
| ||
| 49 | Dominic Oduro | RW | 345 | 63 (34) | 2006-2018 | 0%
| ||
| 73 | Eddie Gaven | RW | 278 | 51 (34) | 2003-2013 | 0%
| ||
| 72 | Eddie Johnson | ST | 201 | 71 (15) | 2001-2007, 2012-2014 | 0%
| ||
| 44 | Edgar Espíndola | ST | 212 | 64 (36) | 2007-2016 | 0%
| ||
| 20 | Edson Buddle | ST | 304 | 100 (21) | 2001-2010, 2012-2015 | 0%
| ||
| 96 | Evander | AM | 87 | 42 (33) | 2023-2025 | 0%
| ||
| 70 | Fafà Picault | LW | 244 | 60 (26) | 2017-2025 | 0%
| ||
| 15 | Fredy Montero | ST | 272 | 85 (42) | 2009-2012, 2017-2018, 2019-2023 | 0%
| ||
| 12 | Jaime Moreno | ST | 255 | 88 (48) | 2000-2010 | 0%
| ||
| 4 | Jeff Cunningham | ST | 312 | 114 (49) | 2000-2011 | 0%
| ||
| 67 | Joao Plata | LW | 211 | 48 (39) | 2011-2019 | 0%
| ||
| 60 | Johnny Russell | RW | 205 | 61 (31) | 2018-2025 | 0%
| ||
| 83 | Juan Pablo Ángel | ST | 152 | 72 (9) | 2007-2012 | 0%
| ||
| 85 | Justin Mapp | RM | 307 | 22 (57) | 2002-2016 | 0%
| ||
| 63 | Kenny Cooper Jr. | ST | 211 | 75 (16) | 2006-2009, 2011-2015 | 0%
| ||
| 53 | Lee Nguyen | AM | 253 | 55 (40) | 2012-2020 | 0%
| ||
| 40 | Maximiliano Urruti | ST | 312 | 72 (30) | 2013-2023, 2025-2026 | 0%
| ||
| 55 | Maxi Moralez | AM | 215 | 30 (63) | 2017-2025 | 0%
| ||
| 39 | Michael Barrios | RW | 272 | 44 (58) | 2015-2023 | 0%
| ||
| 43 | Nicolás Lodeiro | AM | 238 | 42 (58) | 2016-2025 | 0%
| ||
| 89 | Omar Cummings | ST | 184 | 42 (36) | 2007-2014 | 0%
| ||
| 84 | Raúl Ruidíaz | ST | 136 | 71 (9) | 2018-2024 | 0%
| ||
| 87 | Romell Quioto | ST | 150 | 48 (31) | 2017-2023 | 0%
| ||
| 27 | Sacha Kljestan | AM | 329 | 44 (67) | 2006-2010, 2015-2022 | 0%
| ||
| 86 | Sebastián Blanco | AM | 173 | 40 (39) | 2017-2023 | 0%
| ||
| 22 | Steve Ralston | RM | 256 | 54 (65) | 2000-2009 | 0%
| ||
| 32 | Teal Bunbury | ST | 413 | 75 (32) | 2010-2025 | 0%
|