| Ranking | Player | Positions | Nationality | Matches | Goals (assists) | Periods | Clubs | % Correct |
|---|---|---|---|---|---|---|---|---|
| 18 | Andrea Pirlo | MF | 418 | 48 (82) | 2000-2015 | 100%
| ||
| 8 | Daniele De Rossi | DF, MF | 459 | 43 (44) | 2002-2019 | 100%
| ||
| 13 | Francesco Totti | MF, FW | 446 | 207 (115) | 2000-2017 | 100%
| ||
| 3 | Gianluigi Buffon | GK | 523 | 0 (0) | 2000-2005, 2007-2017, 2019-2021 | 100%
| ||
| 16 | Giorgio Chiellini | DF | 430 | 26 (18) | 2004-2005, 2007-2022 | 100%
| ||
| 7 | Goran Pandev | MF, FW | 492 | 101 (49) | 2003-2013, 2015-2022 | 100%
| ||
| 10 | Javier Zanetti | DF, MF | 453 | 3 (15) | 2000-2014 | 100%
| ||
| 15 | Leonardo Bonucci | DF | 431 | 32 (7) | 2005-2006, 2009-2023 | 100%
| ||
| 20 | Marek Hamšík | MF | 409 | 100 (78) | 2004-2005, 2007-2019 | 100%
| ||
| 1 | Samir Handanović | GK | 566 | 0 (0) | 2004-2005, 2007-2023 | 100%
| ||
| 6 | Alberto Gilardino | FW | 497 | 185 (34) | 2000-2017 | 88%
| ||
| 14 | Antonio Di Natale | FW | 444 | 209 (64) | 2002-2016 | 88%
| ||
| 2 | Fabio Quagliarella | FW | 555 | 182 (49) | 2001-2002, 2005-2023 | 88%
| ||
| 23 | Francesco Acerbi | DF | 405 | 24 (8) | 2011-2025 | 88%
| ||
| 4 | Andrea Consigli | GK | 510 | 0 (0) | 2008-2009, 2011-2024 | 63%
| ||
| 5 | Antonio Candreva | DF, MF, FW | 502 | 85 (86) | 2007-2008, 2009-2024 | 63%
| ||
| 22 | Sébastien Frey | GK | 409 | 0 (0) | 2000-2013 | 63%
| ||
| 11 | Lorenzo De Silvestri | DF, MF | 450 | 28 (22) | 2006-2025 | 50%
| ||
| 21 | Morgan De Sanctis | GK | 409 | 0 (0) | 2000-2006, 2009-2016 | 50%
| ||
| 9 | Sergio Pellissier | FW | 455 | 112 (33) | 2002-2006, 2008-2019 | 50%
| ||
| 12 | Dario Dainelli | DF | 446 | 11 (2) | 2000-2018 | 25%
| ||
| 17 | Paolo Cannavaro | DF | 425 | 12 (7) | 2000-2005, 2007-2018 | 25%
| ||
| 19 | Massimo Gobbi | DF, MF | 411 | 12 (26) | 2004-2019 | 13%
| ||
| 24 | Matteo Brighi | MF | 405 | 25 (7) | 2000-2015, 2018-2019 | 0%
|