American Countries Losing the Most People to the Columbian Exchange

Can you guess the modern-day countries in the Americas that lost the most people from 1500-1600 as a result of European powers bringing diseases there?

Using info from Our World in Data

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Last updated: August 1, 2025

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First submitted	August 1, 2025
Times taken	8
Average score	80.0%
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Population Decline	Country	Population (1500)	Population (1600)	Overall Loss (%)
-23.46 M	Mexico	24.46 M	1 M	-96%
-17.85 M	Brazil	18.74 M	888 K	-95%
-2.73 M	Colombia	3.99 M	1.26 M	-68%
-2.7 M	Peru	4 M	1.3 M	-68%
-1.11 M	United States	1.89 M	779 K	-59%
-778 K	Honduras	1.09 M	312 K	-71%
-442 K	Costa Rica	450 K	8 K	-98%
-200 K	Guatemala	800 K	600 K	-25%
-163 K	Nicaragua	325 K	163 K	-50%
-160 K	Haiti	200 K	40 K	-80%