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MODA Chemotherapy - Statistics
General Stats
- This quiz has been taken 4 times
- The average score is 7 of 92
Answer Stats
| Hint | Answer | % Correct | |
|---|---|---|---|
| DHFR Inhibitor | Methotrexate | 100%
| |
| Vinca alkaloid | Vincristine | 100%
| |
| VEGF Inhibitor vs angiogenesis | Bevacizumab | 50%
| |
| Platinum based inhibitor of DNA Pol binding | Cisplatin | 50%
| |
| Anti-Neoplastic Drugs | Alkylating agent, phosphoramide mustard (can't cross BBB) | Cyclophosphamide | 50%
|
| Intercalating Anthracycline (Produces ROS) | Doxorubicin | 50%
| |
| Topo II Inhibitor (Mitoxantrone, anthracyclines, epipodophyllotoxin) | Etoposide | 50%
| |
| Pyrimidine analogue (also inhibits folate synthesis) | FlouroUracil | 50%
| |
| Glucocorticoid Agonist to repress lymphocyte growth | Prednisone | 50%
| |
| ER Antagonist | Tamoxifen | 50%
| |
| Topo I inhibitor (+camptothecin) | Topotecan | 50%
| |
| EGFR (HER2) inhibitor | Trastuzumab | 50%
| |
| Intercalating Anthracycline (Produces ROS) | Actinomycin D | 0%
| |
| Anti-herpes | Purine analogue activated by viral thymidine kinase | Acyclovir | 0%
|
| Anti-influenza (-ve ss RNA) | Inhibits M2 and HA to prevent fusion | Amantadine | 0%
|
| Anti-fungals | Forms pores via ergosterol binding | Amphotericin B | 0%
|
| Aromatase Inhibitor (inhibits Oestrogen Synthesis) | Anastrazole | 0%
| |
| Activated by iron in haem to form free radicals | Artemisinin | 0%
| |
| Hydroxynapthoquinone that mimics ubiquinone to inhibit etc | Atavoquone | 0%
| |
| Thymidine analogue chain terminator | Azidothymidine | 0%
| |
| Antibiotics - Cell wall biosynthesis inhibitors | Bactoprenol dephosphorylation inhibitor (prevents recycling) Made through Lipid I and II intermediates ad bactoprenol carrier | Bacitracin | 0%
|
| metal chelating glycoprotein that intercalates minor groove | Bleomycin | 0%
| |
| IV Nitrosourea | Carmustine | 0%
| |
| EGFR Inhibitor vs colorectal | Cetuximab | 0%
| |
| binds A site to inhibit peptidyl transferase on 50s (overlaps binding site with clindamycin) | Chloramphenicol | 0%
| |
| Anti-malarials | Inhibits haemozin formation (store of toxic haem from Hb digestion by parasite) | Chloroquine | 0%
|
| Cytosine analogue vs CMV | Cidofovir | 0%
| |
| Flouroquinolone, inhibits DNA Gyrase | Ciprofloxacin | 0%
| |
| Chloramphenicol Analogue | Clindamycin | 0%
| |
| Binds Lipid A of LPS to form leaky envelope (polymyxin E) | Colistin | 0%
| |
| Formulation of the above | Co-trimoxazole | 0%
| |
| Aminocoumarin, inhibits GyrB | Coumermycin | 0%
| |
| DNA Binding molecules | Intercalates with bases to stretch backbone | Daunomycin | 0%
|
| D-alanyl-D-alanine synthase +ligase inhibitor | D-Cycloserine | 0%
| |
| Tetracycline Analogue | Doxycycline | 0%
| |
| Anti-HIV | Gp41 analogue - fusion inhibitor | Enfuvirtide | 0%
|
| EGFR TyrK Inhibitor | Erlotinib | 0%
| |
| 50s targeters | Macrolide, binds E site via 23s rRNA on 50S overlaps P site to compete vs peptidyl transferase inhibitors (lincomycin) | Erythromycin | 0%
|
| Triazole that inhibits ergosterol synthesis | Fluconazole | 0%
| |
| Testosterone competitor | Flutamide | 0%
| |
| DNA pol inhibitor, pyrophosphate analogue | Foscarnet | 0%
| |
| Prevents translocation via GTPase+efG inhibition | Fusidic acid | 0%
| |
| Competitive inhibitor of DNA polymerase | Ganciclovir | 0%
| |
| EGFR TyrK Inhibitor | Gefitinib | 0%
| |
| Less toxic aminoglycoside | Gentamycin | 0%
| |
| GnRHR Agonist to increase and inhibit testosterone synthesis | Goserelin | 0%
| |
| Forms transmembrane ion channel upon dimerisation | Gramicidin A | 0%
| |
| Pyramidine analogue - needs viral kinase | Idoxuridine | 0%
| |
| BCR-Abl Inhibitor (TyrK) | Imatinib | 0%
| |
| Drug to preserve some folate synthesis (formyl derivative) | Leucovorin | 0%
| |
| Flouroquinolone, inhibits DNA gyrase | Levofloxacin | 0%
| |
| Oral Nitrosourea | Lomustine | 0%
| |
| CCR5/CXCR4 antagonist | Maraviroc | 0%
| |
| Anti-protozoal | Arsenic pro-drug that inhibits ATP synthesis via TCA cycle, PFK, PDH, Pyruvate kinase inhibition (accumulates in Trypanosomes) | Melarsoprol | 0%
|
| Alkylating agent, melanin precursor analgoue | Melphalan | 0%
| |
| Imidazole that inhibits ergosterol synthesis | Miconazole | 0%
| |
| Alkylates DNA (forms G-G crosslinks between strands) | Mitomycin C | 0%
| |
| Aziridine antibiotic, alkylates DNA | Mitomycin C | 0%
| |
| Intercalating Anthracycline, no ROS production | Mitoxantrone | 0%
| |
| Cytidine Analogue to inhibit RdRP | Molnupiravir | 0%
| |
| Sodium antiporter | Monesin | 0%
| |
| Chloroquine by product, inhibits GyrB | Nalidixic acid | 0%
| |
| Reverse transcriptase inhibitor | Nevirapine | 0%
| |
| Potassium antiporter | Nigericin | 0%
| |
| Alkylating and Carbamoylating agents (can cross BBB) | Nitrosourea | 0%
| |
| Protein Synthesis inhibitors | Inhibits GyrB (topo II ATP binding portion) aminocoumarin | Novobiocin | 0%
|
| Forms pores via ergosterol binding | Nystatin | 0%
| |
| Sialic Acid analogue, pro-drug | Oseltamivir | 0%
| |
| Binds co-operativley on A site with Streptomycin | Paromomycin | 0%
| |
| mimics D-ala-D-ala to inhibit transpeptidase action (beta-lactam ring) | Penicillin | 0%
| |
| DHFR inhibitor pro-drug | Proguanil | 0%
| |
| DHFR inhibitor | Pyrimethamine | 0%
| |
| vDNA integrase inhibitor | Ratelgravir | 0%
| |
| Guanine analogue which inhibits end capping and vRNAPol | Ribavirin | 0%
| |
| Inhibits DNA-dependent RNA Polymerase, binds exit tunnel to prevent elongation | Rifampin | 0%
| |
| Protease inhibitor | Ritonavir | 0%
| |
| Protease inhibtor | Saquinavir | 0%
| |
| Leishmaniasis (has ergosterol in membrane) | Inhibits Topo I and ATP synthesis | Sodium Stibogluconate | 0%
|
| Inhibits elongation factor G | Spectinomycin | 0%
| |
| Aminoglycoside binds 30s + nephrotoxic + ototoxic | Streptomycin | 0%
| |
| DHFS inhibitor | Sulfadoxin | 0%
| |
| Anti-metabolites | Inhibits Dihydropteroate Synthase (sulfonamide) | Sulfamethazole | 0%
|
| Inhibits reoxidation of NADH and ATP synthesis | Suramin | 0%
| |
| blocks translocation at 50s (is synergistic combination) | Synercid | 0%
| |
| Prevents remodelling of microtubules | Taxol | 0%
| |
| Ribosome Targeters | Aminoglycoside binds A site on 16s rRNA on 30s (bacteriostatic) | Tetracycline | 0%
|
| Pyramidine analogue - doesn't need viral kinase | Trifuridine | 0%
| |
| Inhibits Dihydrofolate reductase (diaminopyrimidines) | Trimethoprim | 0%
| |
| Membrane targetting drugs | Forms potassium uniport | Valinomycin | 0%
|
| Binds D-ala-D-ala to modify lipid 2 and inhibit transglycosylase action | Vancomycin | 0%
| |
| Vinca alkaloid inhibitor of tublin polymerisation | Vinblastine | 0%
| |
| Sialic Acid analogue to inhibit NA | Zonamivir | 0%
|
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