I also. Never heard of the other one. The UK one was founded in 995 although a settlement probably existed there since around 2000BC. I presume that the Durham mentioned in the question must have a longer history than that?
Qatar, Queensland, Qingdao, Quebec, Queens, Quezon City, Quito, Quintana Roo, Queen Maud's Land, Quantico. There's a few answers that wouldn't be too obsucre in my opinion.
The Durham/Chapel Hill question is very obscure for people outside of the US, maybe say in the question this is about the Durham in the USA to at least point in the right direction?
Raleigh, Durham, and Chapel Hill are the centers of the Research Triangle of world-class universities, medical schools, and high-tech businesses. It isn't obscure, but probably not as well known outside of the US.
Was gonna complain about the Durham one, but it’s all been said more than a few times… Chapel Hill is not in the UK, so it didn’t take long to start guessing US cities beginning with R. Funny comments about Transylvania as well.
The question should really state that the Durham quoted is the one in the US.
CH being the oldest public school in the US, and are part of a massive growing urban area they aren't extremely obscure
(In this case, the inclusion of Chapel Hill is sufficient to disambiguate it, so I argue the clue is fine as-is, but that's the contention anyway.)
https://en.wikipedia.org/wiki/Hungarian_irredentism