Keep scrolling down for answers and more stats ...
1.
Using The Bible during the Mom fight instantly kills her.
Also works on Mom's Heart and It Lives!
2.
Using the Bible during the Satan fight instantly kills you.
3.
Arcades can only appear on odd numbered floors.
Arcades only appear on even-numbered floors.
4.
Rotten Meat is a health and attack up.
Rotten Meat only increases health.
5.
Hush can only be fought if Mom's Heart / It Lives! is defeated within 1 hour of starting a run.
The time limit for defeating Mom's Heart / It Lives! is 30 minutes.
6.
Killing the boss of Chapter 1 in under a minute causes all secret rooms on the floor to be revealed.
It causes the Broken Shovel to fall from the trapdoor in the spawn room.
7.
The Siren is guaranteed to drop the Forgotten Lullaby only the first time her skull is destroyed.
The Siren only drops the trinket the first time her skull is bombed. (a Host spawns every time afterward)
8.
Clicker instantly kills Dogma when still connected to the television.
Not really but can you imagine?
9.
Mother and Mom refer to two different bosses.
Thanks Edmund
10.
Entering the mirror in Downpour instantly kills you if you have Charm of the Vampire.
It still works, but you can't see your reflection in the water.