Year
|
Location
|
Deaths
|
Symptoms
|
Disease
|
735–737
|
Japan
|
2,000,000
|
Scabs, Fever, Aching
|
Smallpox
|
~1000
|
Europe
|
Unknown
|
Joint Pain, Lightly colored patches, numbness
|
Leprosy
|
1346–1353
|
Eurasia and Northern Africa
|
75,000,000 – 200,000,000
|
Pneumonia, Blackened Skin, Vomiting
|
Bubonic Plague (Black Death)
|
1500s - 1800s
|
Central America
|
5,000,000–15,000,000
|
High fever, Vertigo, Dysentery
|
Cocoliztli (Salmonella)
|
1592–1596
|
Seneca Nation (USA and Canada)
|
Unknown
|
Watery Eyes, Rashes, Runny Nose
|
Measles
|
1700s–1800s
|
Europe
|
Unknown
|
Night Sweats, Coughing Blood, Weight loss
|
Tuberculosis
|
1735–1741
|
United States and British North America
|
20,000
|
Bluish Skin, Drooling, Painful Swallowing
|
Diphtheria
|
1793
|
Philadelphia
|
>5,000
|
Jaundice, Fever, Vomiting
|
Yellow Fever
|
1829
|
Netherlands
|
2,800
|
Fatigue, Headache, Vomiting
|
Malaria
|
1846–1860
|
Worldwide
|
>1,000,000
|
Diarrhea, Cramps, Thirst
|
Cholera
|
1866
|
Finland (Russian Empire)
|
270,000
|
Fast Breathing, Nausea, Aching
|
Typhus
|
1900s–Present
|
Worldwide
|
40,100,000
|
Rashes, Sore Throat, Fatigue
|
HIV/AIDS
|
1918–1920
|
Worldwide
|
25,000,000 – 50,000,000
|
Dry Cough, Chills, Loss of Appetite
|
Spanish Flu (Influenza)
|
2013–2016
|
West Africa
|
~11,000
|
Tiredness, Red Eyes, Nausea
|
Ebola
|
2019–Present
|
Worldwide
|
|
Fever, Dry Cough, Runny Nose
|
COVID-19
|
|