Next Big City on the Interstate

Given a starting city, an interstate, and a direction, name the next city with a population over 200,000 on that interstate.
The interstate must actually touch the city limits (including forming part of the boundary of the city) in order for it to count.
Three-digit loop and spur roads (ex. 405) do not count. Split interstates (ex. 35 splits into 35E and 35W) do count.
200,000 refers to the city proper population, based on the 2017 estimates from this source.
For reference, there are roughly 110 cities in the U.S. that fit this criterion.
Quiz by cornflakesfu
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Last updated: June 23, 2018
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First submittedJune 23, 2018
Times taken63
Average score65.0%
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Origin and Route
Next City
From Jacksonville, head west on I-10
New Orleans
From Dallas, head east on I-20
Birmingham
From Denver, head south on I-25
Colorado Springs
From San Antonio, head south on I-35
Laredo
From Memphis, head west on I-40
Oklahoma City
From Oklahoma City, head east on I-44
Tulsa
From Houston, head north on I-45
Dallas
From Chicago, head south on I-55
St. Louis
From Louisville, head east on I-64
Lexington
From Nashville, head north on I-65
Louisville
Origin and Route
Next City
From Indianapolis, head north on I-69
Fort Wayne
From Baltimore, head west on I-70
Columbus
From Columbus, head south on I-71
Cincinnati
From Detroit, head south on I-75
Toledo
From Charlotte, head north on I-77
Cleveland
From San Francisco, head east on I-80
Oakland
From Portland, head east on I-84
Boise
From Seattle, head east on I-90
Spokane
From Milwaukee, head west on I-94
Madison
From New York, head south on I-95
Newark
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