Keep scrolling down for answers and more stats ...
Actor/Actress
Description
Character
Tobey Maguire
A brilliant physics student at Columbia University and photographer for the Daily Bugle who gets spider-like abilities from a radioactive spider and uses them to take up the persona of a spider-based vigilante protecting New York City from its criminal underworld
Peter Parker / Spider-Man
Kirsten Dunst
A Broadway actress and Peter's childhood girlfriend
Mary Jane Watson
James Franco
The dedicated son of Norman Osborn and Peter's estranged best friend, who believes Spider-Man murdered his father, but after learning Peter is Spider-Man and his father was the Green Goblin, he tends to battle Peter directly as a psychopathic assassin armed with the same equipment as his father
Harry Osborn / New Goblin
Thomas Haden Church
A small-time thug with an estranged wife and sick daughter, whose struggle to rob for money to get his daughter treatment lures him into a freak accident that alters him into a master sand manipulator hunted by Spider-Man since he was Peter's uncle Ben's true killer
Flint Marko / Sandman
Topher Grace
A rival Daily Bugle photographer who is exposed by Peter for creating a fake image of Spider-Man, and is ready for revenge when he bonds with the symbiote, turning him into monstrous being with the same spider-like powers
Eddie Brock / Venom
Bryce Dallas Howard
Peter's lab partner and good friend, who is saved by Spider-Man from falling to her death
Gwen Stacy
Rosemary Harris
Peter's aunt, who gives her nephew her engagement ring so he can propose to Mary Jane, and teaches him forgiveness
May Parker
J.K. Simmons
The aggressive chief of the Daily Bugle who despises Spider-Man
J. Jonah Jameson
James Cromwell
Gwen's father and a New York City Police Department Captain
Captain George Stacy
Theresa Russel
Flint's wife
Emma Marko
Dylan Baker
Peter's college physics professor who examines a piece of the symbiote and tells Peter it "amplifies characteristics of its host… especially aggression"
Dr. Curt Connors
Actor/Actress
Description
Character
Bill Nunn
A longtime employee at the Daily Bugle
Joseph "Robbie" Robertson
Elizabeth Banks
Jameson's receptionist at the Daily Bugle
Betty Brant
Ted Raimi
A Daily Bugle employee who suggests a catchphrase to Jameson
Hoffman
Perla Haney-Jardine
Flint and Emma's sick daughter
Penny Marko
Willem Dafoe
The hallucination of Harry's late father who encourages his son to destroy Spider-Man
Norman Osborn / Green Goblin
Cliff Robertson
Peter's deceased uncle
Ben Parker
Elya Baskin
Peter's landlord who is greedy for Peter's rent
Dr. Ditkovitch
Mageina Tovah
The unassuming daughter of Dr. Ditkovitch
Ursula Ditkovitch
Michael Papajohn
A carjacker who was believed to have murdered Peter's uncle Ben
Dennis Carradine
Joe Manganiello
Mary Jane's former boyfriend and a bully to Peter from the original film