Degen Regen References

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Last updated: May 11, 2018
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First submittedMay 11, 2018
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Author
Date
Methods
OEC rat thoracic spinal transections
Ramon-Cueto
2003
-
Rat CST lesion OEC transplant, cells do not pass scar but functional recovery
Yamamoto
2009
high power imaging
OEC injections dogs w contusive spinal cord injury--> increased hindlimb coordination but no long tract improvement
Granger
2012
-
Paralysed man regained some function post OEC transplant
Tabakow
2014
-
Antibodies versus TGFbeta1,2 decreases astrocytic response
Moon
2001
GFAP immunohistochemistry
Ablation of astrocytes in mice increased oedema, leukocyte recruitment, BBB permeability and neuronal loss v WT
Bush
1999
-
STAT3 selective KO mice
Wanner
2013
 
Rho inhibition--> neurite extension to previously inhibitory stripes, CSPG inhibition usually leads to Rho-mediated growth cone collapse
Monnier
2003
-
Intrathecal ChABC injections increased fibres crossing a lesion (cats)
Bradbury
2002
-
ChABC increased sprouting (rat sensorimotor cortex), very limited regeneration
Garcia-Alias
2009
(Also Shield 2008)
Rolipram (PDE IV inhibitor) reduced astrocyte activation, enhanced serotenergic fibre regeneration.
Nikulina
2004
GFAP stain, then 5-HT immunohistochemistry
Cells overexpressing alpha synuclein have defective exocytosis
Nemani
2010
pHlourin
Alpha synuclein KO mice have greater vesicle availability
Abeliovich
2000
-
Alpha synuclein enhances DAT transport to the membrane
Lee
2001
Co-expression of alpha-synuclein, DAT
Increased VMAT2 when alpha-synuclein is knocked down
Fountaine
2008
in vitro alpha synuclein knockdown
Cells overexpressing alpha synuclein have impaired chaperone-mediated autophagy; Rab localisation is massively altered in yeast overexpressing alpha synuclein
Xilouri
2009
-
Alpha synuclein increases mitochondrial fragmentation
Kamp
2010
-
Parkin mutations, Pink1 mutations decrease number of DAergic neurons in the brain; the expression of parkin rescued both phenotypes
Park
2006
Drosophila
DJ-1 mutation causes mitochondrial dysfunction, DJ-1 expression can rescue Pink1 mutants
Hao
2010
DJ-1 mutant flies
LRRK2 is specifically localised in lysosomal-autophagic organelles; knockdown of LRRK2 increases LC-III turnover and autophagy
Wade-Martins
2009
siRNA knockdown
hESC derived DAergic midbrain neurons implanted to mouse PD model, MPTP-lesioned Rhesus monkeys
Kriks
2011
hESCs differentiated to DAergic midbrain neurons
iPSCs succesfully converted from fibroblasts into midbrain neurons
Pfisterer
2011
-
Greater Abeta42 deposition in ApoE homozygotes; also increased plaque binding (PET)
Castellano
 
Cognitively normal >70y.o; PET (PIB-radiotracer (plaque))
Induced KO of ApoE in hippocampus reduced insoluble Abeta42 by 50% in hAPP mice
Bien-Ly
2012
KI human ApoEepsilon4 flanked by loxP; Cre recombinase to KO in hippocampus of hAPP mice
Very little degeneration of Tau KO hippocampal neurons when cultured in Abeta (versus WT)
Rapoport
2002
Tau KO, Abeta culture
Abeta activates NMDARs, which can be partially blocked by subunit antagonism
Li
2011
-
There is very little neuroanatomical or temporal correlation between plaques and degen.
Braak
1991
 
Abeta oligomers cause neuron death
Jean
2015
Infused Abeta oligomers to hippocampi of mice
There is a strong positive correlation between Abeta oligomers and Tau pathology
Lesne
2013
-
Accumulation of autophagosomes in neurons from AD brains
Nixon
2005
-
Less acidity of lysosomes in presenelin KO mice
Lee
2010
Immunofluorescent labelling
ApoE epsilon4 expression increased lysosomal leakage compared to ApoE epsilon3
Ji
2005
ApoE epsilon4 expression in vitro neurons
Inhibition of lysosomal proteolysis led to accumulation of electron-dense autophagosomes
Boland
2008
Inhibited cysteine proteases
Deletion of lysosomal cathepsin inhibitor in hAPP mice decreased e.c. amyloid, giant autolysosomes and caused behavioural improvements
Yang
2011
 
iPSCs from AD patients can be used to screen drugs, the subsequent neurons had increased Abeta secretion, phosphorylated Tau and activated GSK-3beta
Israel
2012
 
mAb versus ApoE reduced Abeta plaque load in hAPP mice, also recruited microglia
Basak
2012
 
Intracerebroventricular injection of Abs versus IL-12,IL-23 (microglial cytokines) decreased amyloid in hAPP mice and improved cognition
Vom Berg
2012
-
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