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pharmacokinetic equations

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camisadorising
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Last updated: April 19, 2023
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First submittedApril 19, 2023
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Hint
Answer
If 180 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 76 μg/100mL, what is the apparent volume of distribution of the drug?
236.8 L
If 160 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 27 μg/100mL, what is the apparent volume of distribution of the drug?
592.6 L
Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 60 μg/mL. Assuming the apparent volume of distribution is 10% of an average body weight of 90 kg, calculate the total amount of drug present in body fluids four hours after administration.
540 mg
A drug has an elimination rate constant of 0.277 hr-1. Its elimination half-life is:
2.5 hrs
Assuming complete absorption and an elimination half-life of 4 hours, how many mg of a drug will remain in the body 25 hours after administering a 100 mg dose?
1.314 mg
Hint
Answer
A drug has an elimination rate constant of 0.510 hr-1. Its elimination half-life is:
1.36 hrs
The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients.

The results were as follows: intravenous bolus AUC = 8500 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 830 mg . h/L. What is the bioavailability of the oral liquid?
0.098 or 9.8%
What is the plasma concentration of a drug when 200 mg is given by IV bolus to a 65kg patient if her volume of distribution is 16 L/kg.
0.192 mg/L
What is the plasma concentration of a drug when 900 mg is given by IV bolus to a 100kg patient if her volume of distribution is 7.7L/kg.
1.169 mg/L
What is the plasma concentration of a drug when 700 mg is given by IV bolus to a 220lb patient if her volume of distribution is 35 L/kg. (Please note that 1kg = 2.2lb)
0.2 mg/L
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