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pharmacokinetic equations - Statistics
General Stats
- This quiz has been taken 27 times
- The average score is 6 of 10
Answer Stats
| Hint | Answer | % Correct |
|---|---|---|
| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 7500 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 220 mg . h/L. What is the bioavailability of the oral liquid? | 0.029 or 2.9% | 100%
|
| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 7300 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 940 mg . h/L. What is the bioavailability of the oral liquid? | 0.128 or 12.8% | 100%
|
| What is the plasma concentration of a drug when 200 mg is given by IV bolus to a 65kg patient if her volume of distribution is 16 L/kg. | 0.192 mg/L | 100%
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| If 500mg of a drug is administered orally and 50mg is absorbed unchanged, the bioavailability of the drug is: | 0.1 or 10.0% | 100%
|
| What is the plasma concentration of a drug when 700 mg is given by IV bolus to a 220lb patient if her volume of distribution is 35 L/kg. (Please note that 1kg = 2.2lb) | 0.2 mg/L | 100%
|
| Calculate the elimination rate constant for a drug having an elimination half-life of 54 minutes. | 0.77/hr | 100%
|
| A single intravenous dose of 40 mg of diazepam was administered to a patient. A blood sample was drawn and it contained 50 µg/mL. Calculate the apparent volume of distribution for the drug. | 0.8 L | 100%
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| A drug has an elimination rate constant of 0.702 hr-1. Its elimination half-life is: | 0.99 hrs | 100%
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| Calculate the elimination rate constant for a drug having an elimination half-life of 41 minutes. | 1.01/hr | 100%
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| If 550 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 25 μg/100mL, what is the apparent volume of distribution of the drug? | 2200 L | 100%
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| A drug has an elimination rate constant of 0.296 hr-1. Its elimination half-life is: | 2.34 hrs | 100%
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| A drug has an elimination rate constant of 0.277 hr-1. Its elimination half-life is: | 2.5 hrs | 100%
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| Calculate the elimination rate constant for a drug having an elimination half-life of 15 minutes. | 2.77/hr | 100%
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| What is the plasma concentration of a drug when 700 mg is given by IV bolus to a 80kg patient if her volume of distribution is 3.5L/kg. | 2 mg/L | 100%
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| Assuming complete absorption and an elimination half-life of 5 hours, how many mg of a drug will remain in the body 35 hours after administering a 400 mg dose? | 3.125 mg | 100%
|
| Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 60 μg/mL. Assuming the apparent volume of distribution is 10% of an average body weight of 90 kg, calculate the total amount of drug present in body fluids four hours after administration. | 540 mg | 100%
|
| The volume of distribution of a drug is 19 L with a blood concentration of 3 mg/L. Calculate the total amount of drug present in the patient. | 57 mg | 100%
|
| The volume of distribution of a drug is 15 L with a blood concentration of 4 μg/mL. Calculate the total amount of drug present in the patient. | 60 mg | 100%
|
| If 680 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 98 μg/100mL, what is the apparent volume of distribution of the drug? | 693.8 L | 100%
|
| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 8500 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 830 mg . h/L. What is the bioavailability of the oral liquid? | 0.098 or 9.8% | 75%
|
| A single intravenous dose of 73 mg of diazepam was administered to a patient. A blood sample was drawn and it contained 47 µg/mL. Calculate the apparent volume of distribution for the drug. | 1.55 L | 67%
|
| Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 30 μg/mL. Assuming the apparent volume of distribution is 10% of an average body weight of 75 kg, calculate the total amount of drug present in body fluids four hours after administration. | 225 mg | 67%
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| If 975mg of a drug is administered orally and 95mg is absorbed unchanged, the bioavailability of the drug is: | 0.097 or 9.7% | 60%
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| If 480mg of a drug is administered orally and 20mg is absorbed unchanged, the bioavailability of the drug is: | 0.04 or 4.0% | 50%
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| What is the plasma concentration of a drug when 400 mg is given by IV bolus to a 100kg patient if her volume of distribution is 54 L/kg. | 0.074 mg/L | 50%
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| If 470mg of a drug is administered orally and 70mg is absorbed unchanged, the bioavailability of the drug is: | 0.149 or 14.9% | 50%
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| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 2500 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 650 mg . h/L. What is the bioavailability of the oral liquid? | 0.26 or 26.0% | 50%
|
| What is the plasma concentration of a drug when 800 mg is given by IV bolus to a 90kg patient if her volume of distribution is 25 L/kg. | 0.355 mg/L | 50%
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| A drug has an elimination rate constant of 0.845 hr-1. Its elimination half-life is: | 0.82 hrs | 50%
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| A single intravenous dose of 64 mg of diazepam was administered to a patient. A blood sample was drawn and it contained 68 µg/mL. Calculate the apparent volume of distribution for the drug. | 0.94 L | 50%
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| Assuming complete absorption and an elimination half-life of 4 hours, how many mg of a drug will remain in the body 25 hours after administering a 100 mg dose? | 1.314 mg | 50%
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| Assuming complete absorption and an elimination half-life of 8 hours, how many mg of a drug will remain in the body 40 hours after administering a 500 mg dose? | 15.625 mg | 50%
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| A drug has an elimination rate constant of 0.355 hr-1. Its elimination half-life is: | 1.95 hrs | 50%
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| Calculate the elimination rate constant for a drug having an elimination half-life of 19 minutes. | 2.19/hr | 50%
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| If 180 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 76 μg/100mL, what is the apparent volume of distribution of the drug? | 236.8 L | 50%
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| Assuming complete absorption and an elimination half-life of 12 hours, how many mg of a drug will remain in the body 90 hours after administering a 700 mg dose? | 3.867 mg | 50%
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| The volume of distribution of a drug is 82 L with a blood concentration of 7 μg/mL. Calculate the total amount of drug present in the patient. | 574 mg | 50%
|
| If 160 mg of a drug are administered intravenously and the resultant drug plasma concentration is determined to be 27 μg/100mL, what is the apparent volume of distribution of the drug? | 592.6 L | 50%
|
| Calculate the elimination rate constant for a drug having an elimination half-life of 36 minutes. | 1.16/hr | 33%
|
| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 3800 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 440 mg . h/L. What is the bioavailability of the oral liquid? | 0.116 or 11.6% | 25%
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| The volume of distribution of a drug is 5400 mL with a blood concentration of 8 μg/mL. Calculate the total amount of drug present in the patient in mg. | 43.2 mg | 25%
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| Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 70 μg/mL. Assuming the apparent volume of distribution is 15% of an average body weight of 85 kg, calculate the total amount of drug present in body fluids four hours after administration. | 892.5 mg | 20%
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| If 720mg of a drug is administered orally and 95mg is absorbed unchanged, the bioavailability of the drug is: | 0.132 or 13.2% | 0%
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| If 2400mg of a drug is administered orally and 380mg is absorbed unchanged, the bioavailability of the drug is: | 0.158 or 15.8% | 0%
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| The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 2900 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 980 mg . h/L. What is the bioavailability of the oral liquid? | 0.338 or 33.8% | 0%
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| A single intravenous dose of 28 mg of diazepam was administered to a patient. A blood sample was drawn and it contained 55 µg/mL. Calculate the apparent volume of distribution for the drug. | 0.51 L | 0%
|
| Calculate the elimination rate constant for a drug having an elimination half-life of 48 minutes. | 0.87/hr | 0%
|
| Assuming complete absorption and an elimination half-life of 10 hours, how many mg of a drug will remain in the body 60 hours after administering a 650 mg dose? | 10.156 mg | 0%
|
| What is the plasma concentration of a drug when 900 mg is given by IV bolus to a 100kg patient if her volume of distribution is 7.7L/kg. | 1.169 mg/L | 0%
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| A drug has an elimination rate constant of 0.510 hr-1. Its elimination half-life is: | 1.36 hrs | 0%
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| What is the plasma concentration of a drug when 300 mg is given by IV bolus to a 220lb patient if her volume of distribution is 1.1L/kg. (Please note that 1kg = 2.2lb) | 2.727 mg/L | 0%
|
| What is the plasma concentration of a drug when 800 mg is given by IV bolus to a 75kg patient if her volume of distribution is 2.1L/kg. | 5.080 mg/L | 0%
|
| Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 40 μg/mL. Assuming the apparent volume of distribution is 20% of an average body weight of 75 kg, calculate the total amount of drug present in body fluids four hours after administration. | 600 mg | 0%
|
| Assuming complete absorption and an elimination half-life of 8 hours, how many mg of a drug will remain in the body 42 hours after administering a 350 mg dose? | 9.197 mg | 0%
|
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