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Future Medicines

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RieseJB
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Last updated: June 3, 2024
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First submittedJune 3, 2024
Times taken10
Average score31.6%
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IL-1 antagonist for RA
anakinra
JAK inhibitor for RA
tofacitinib
Anti-CD20 antibodies for MS and RA
rituximab
IL-6R inhibitor for RA
tocilizumab
IL-6 inhibitor for RA
sirukumab
Bound IL-6R inhibitor preventing gp130 binding
olamkicept
IL-6 inhibitor to prevent gp130 binding for RA and covid
olokizumab
TNFa inhibitor
infliximab
TNFa inhibitor
adalimumab
Fusion protein of 2 soluble TNFaRs
etanercept
DMARD increasing PPARy activation for RA and UC
mesalazine
DMARD inhibitor of calcineurin for RA, UC and organ rejection
cyclosporin
DMARD - dihydrofolate reductase inhibitor to inhibit thymine
methotrexate
DMARD inhibiting purine synthesis
azathioprine
What previous is converted into to inhibit amidophosphoribosyltransferase
mercaptopurine
siRNA to inhibit IC synthesis of PCSK9
inclisiran
siRNA to interfere with production of apolipoprotein a
olpasiran
Inhibitor of PCSK9
alirocumab
HMG CoA reductase inhibition, increase LDLR expression
statins
Block receptor to prevent aldosterone release, AT1R antagonists
losartan
Reduce aldosterone production, reduce blood pressure, ACEIs
captopril
Loop diuretic specific for pulmonary oedema, prevents salt/water retention
furosemide
Aldosterone receptor antagonist reversing left ventricular hypertrophy
spironolactone
B-adrenoceptor antagonists to slow heart rate, anti-arrhythmic
propanolol
SGLT2 inhibitors preventing glucose reabsorption in kidneys, no hr effect
dapagliflozin
Stimulates GC in absence of NO increasing renal blood flow, vasodilation
vericiguat
Neprilysin inhibitor
sacubitril
IL-5R inhibitor, preventing IL-5 activation of baso/eosinophils
benralizumab
TSLP (alarmin) inhibitor to reduce expression with allergen presence
tezepelumab
PDE3 selective inhibitor
enoximone
PDE4 selective inhibitor
roflumilast
Non-selective inhibitor of both PDE3 and 4
ensifentrine
CFTR channel potentiator
ivacaftor
CFTR protein folding corrector
tezacaftor
Chaperone for CFTR folding, increases CFTR at membrane
lumacaftor
P2X3 inhibitor on sensory nerves for cough
gefapixant
Blocks presynaptic Na+ channels to prevent glutamate transmission
riluzole
Anti-oxidant, aiding in protection from free radicals
edaravone
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