Future Medicines

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Last updated: June 3, 2024

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Hint	Answer
IL-1 antagonist for RA	anakinra
JAK inhibitor for RA	tofacitinib
Anti-CD20 antibodies for MS and RA	rituximab
IL-6R inhibitor for RA	tocilizumab
IL-6 inhibitor for RA	sirukumab
Bound IL-6R inhibitor preventing gp130 binding	olamkicept
IL-6 inhibitor to prevent gp130 binding for RA and covid	olokizumab
TNFa inhibitor	infliximab
TNFa inhibitor	adalimumab
Fusion protein of 2 soluble TNFaRs	etanercept
DMARD increasing PPARy activation for RA and UC	mesalazine
DMARD inhibitor of calcineurin for RA, UC and organ rejection	cyclosporin
DMARD - dihydrofolate reductase inhibitor to inhibit thymine	methotrexate
DMARD inhibiting purine synthesis	azathioprine
What previous is converted into to inhibit amidophosphoribosyltransferase	mercaptopurine
siRNA to inhibit IC synthesis of PCSK9	inclisiran
siRNA to interfere with production of apolipoprotein a	olpasiran
Inhibitor of PCSK9	alirocumab
HMG CoA reductase inhibition, increase LDLR expression	statins

Hint	Answer
Block receptor to prevent aldosterone release, AT1R antagonists	losartan
Reduce aldosterone production, reduce blood pressure, ACEIs	captopril
Loop diuretic specific for pulmonary oedema, prevents salt/water retention	furosemide
Aldosterone receptor antagonist reversing left ventricular hypertrophy	spironolactone
B-adrenoceptor antagonists to slow heart rate, anti-arrhythmic	propanolol
SGLT2 inhibitors preventing glucose reabsorption in kidneys, no hr effect	dapagliflozin
Stimulates GC in absence of NO increasing renal blood flow, vasodilation	vericiguat
Neprilysin inhibitor	sacubitril
IL-5R inhibitor, preventing IL-5 activation of baso/eosinophils	benralizumab
TSLP (alarmin) inhibitor to reduce expression with allergen presence	tezepelumab
PDE3 selective inhibitor	enoximone
PDE4 selective inhibitor	roflumilast
Non-selective inhibitor of both PDE3 and 4	ensifentrine
CFTR channel potentiator	ivacaftor
CFTR protein folding corrector	tezacaftor
Chaperone for CFTR folding, increases CFTR at membrane	lumacaftor
P2X3 inhibitor on sensory nerves for cough	gefapixant
Blocks presynaptic Na+ channels to prevent glutamate transmission	riluzole
Anti-oxidant, aiding in protection from free radicals	edaravone

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