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Deadliest Pandemics/Epidemics in History

Can you guess the pandemics that killed the most people throughout world history? The estimated death toll (as of 2025) and years for each disease are given.
It's difficult to accurately estimate many of these death tolls, so take it with a grain of salt
Data from Wikipedia
When typing answers, do not include years in your answer. They will not work
Quiz by
OvenBobat
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Last updated: December 5, 2025
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First submittedDecember 5, 2025
Times taken102
Average score52.6%
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Death Toll
Years
Disease
15–100 million
541–549
Plague of Justinian
44 million
1981–present
HIV/AIDS pandemic
25–50 million
1346–1353
Black Death
25–50 million
1918–1920
Spanish Influenza Pandemic
7.1–36.5 million
2019–present
COVID-19 Pandemic
12–15 million
1855–1960
Third Plague Pandemic
5–15 million
1545–1548
First Cocoliztli Epidemic
5–10 million
165–190
Antonine Plague
5–8 million
1519–1520
Mexico Smallpox Epidemic
1–4 million
1957–1958
Asian Flu Pandemic
Death Toll
Years
Disease
1–4 million
1968–1969
Hong Kong Flu
2–3 million
1918–1922
Russia Typhus Epidemic
2–2.5 million
1576–1580
Second Cocoliztli Epidemic
2 million
1772–1773
Persian Plague
2 million
735–737
Japanese Smallpox Epidemic
1.25 million
1656–1658
Naples Plague
1 million
1889–1890
Russian Flu
1 million
1629–1631
Great Plague of Milan
1 million
1846–1860
Third Cholera Pandemic
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1 Comments
OvenBobat
+1
Level 65
Dec 5, 2025
The Black Death is often estimated to be deadlier, but it's very unlikely considering the population of the world at the time.
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