|
Rank
|
Drug
|
Total Prescriptions
|
Drug Class
|
|
1
|
Atorvastatin
|
109,582,746
|
Lipid-lowering agent
|
|
2
|
Metformin
|
86,747,907
|
Antidiabetic
|
|
3
|
Lisinopril
|
82,513,967
|
ACE inhibitor
|
|
4
|
Levothyroxine
|
82,431,914
|
Synthetic hormone
|
|
5
|
Amlodipine
|
70,766,211
|
Calcium channel blocker
|
|
6
|
Metoprolol
|
65,245,216
|
Beta blocker
|
|
7
|
Salbutamol
|
59,079,269
|
SABA
|
|
8
|
Losartan
|
53,555,510
|
Angiotensin II receptor blocker
|
|
9
|
Omeprazole
|
52,132,950
|
Proton-pump inhibitor
|
|
10
|
Gabapentin
|
40,141,486
|
Anticonvulsant
|
|
11
|
Sertraline
|
39,891,990
|
Antidepressant
|
|
12
|
Hydrochlorothiazide
|
38,153,288
|
Diuretic
|
|
13
|
Rosuvastatin
|
37,095,971
|
Lipid-lowering agent
|
|
14
|
Dextroamphetamine; Amphetamine
|
34,690,297
|
Psychostimulant
|
|
15
|
Escitalopram
|
30,750,612
|
Antidepressant
|
|
16
|
Pantoprazole
|
30,670,528
|
Proton-pump inhibitor
|
|
17
|
Montelukast
|
29,187,952
|
Antileukotriene
|
|
18
|
Trazodone
|
27,363,318
|
Antidepressant
|
|
19
|
Simvastatin
|
26,459,069
|
Lipid-lowering agent
|
|
20
|
Tamsulosin
|
25,306,357
|
Alpha blocker
|
|
21
|
Bupropion
|
25,197,923
|
Antidepressant
|
|
22
|
Fluoxetine
|
24,014,263
|
Antidepressant
|
|
23
|
Acetaminophen; Hydrocodone
|
23,521,228
|
Analgesic
|
|
24
|
Furosemide
|
23,067,424
|
Diuretic
|
|
25
|
Fluticasone
|
22,557,458
|
Glucocorticoid
|
|
26
|
Amoxicillin
|
20,465,164
|
Antibiotic
|
|
27
|
Apixaban
|
19,420,949
|
Anticoagulant
|
|
28
|
Insulin Glargine
|
18,983,905
|
Antidiabetic
|
|
29
|
Meloxicam
|
18,859,721
|
NSAID
|
|
30
|
Prednisone
|
18,201,857
|
Glucocorticoid
|
|
31
|
Duloxetine
|
18,066,468
|
Antidepressant
|
|
32
|
Methylphenidate
|
17,705,265
|
Psychostimulant
|
|
33
|
Ibuprofen
|
17,493,911
|
NSAID
|
|
34
|
Carvedilol
|
17,067,595
|
Beta blocker
|
|
35
|
Potassium Chloride
|
16,993,841
|
Electrolyte
|
|
36
|
Aspirin
|
16,981,811
|
NSAID
|
|
37
|
Pravastatin
|
16,317,126
|
Lipid-lowering agent
|
|
38
|
Ergocalciferol
|
15,914,322
|
Vitamin
|
|
39
|
Allopurinol
|
15,235,132
|
Antigout agent
|
|
40
|
Citalopram
|
15,047,663
|
Antidepressant
|
|
41
|
Alprazolam
|
14,988,526
|
Benzodiazepine
|
|
42
|
Glipizide
|
14,521,604
|
Antidiabetic
|
|
43
|
Cetirizine
|
13,899,342
|
Antihistamine
|
|
44
|
Venlafaxine
|
13,881,022
|
Antidepressant
|
|
45
|
Cyclobenzaprine
|
13,724,245
|
Muscle relaxant
|
|
46
|
Hydroxyzine
|
13,652,751
|
Antihistamine
|
|
47
|
Clopidogrel
|
13,568,821
|
Antiplatelet agent
|
|
48
|
Semaglutide
|
13,523,981
|
Antidiabetic
|
|
49
|
Famotidine
|
13,156,330
|
H2 blocker
|
|
50
|
Estradiol
|
12,622,775
|
Synthetic hormone
|
|
|
Rank
|
Drug
|
Total Prescriptions
|
Drug Class
|
|
51
|
Diclofenac
|
12,480,262
|
NSAID
|
|
52
|
Spironolactone
|
12,450,600
|
Diuretic
|
|
53
|
Hydrochlorothiazide; Lisinopril
|
12,335,355
|
Diuretic + ACE inhibitor
|
|
54
|
Buspirone
|
12,332,589
|
Anxiolytic
|
|
55
|
Tramadol
|
12,203,197
|
Analgesic
|
|
56
|
Empagliflozin
|
12,009,951
|
Antidiabetic
|
|
57
|
Clonazepam
|
11,711,065
|
Benzodiazepine
|
|
58
|
Lamotrigine
|
11,704,668
|
Anticonvulsant
|
|
59
|
Fluticasone; Salmeterol
|
11,570,693
|
Glucocorticoid + LABA
|
|
60
|
Oxycodone
|
11,314,082
|
Analgesic
|
|
61
|
Ondansetron
|
10,880,346
|
Antiemetic
|
|
62
|
Cholecalciferol
|
10,833,991
|
Vitamin
|
|
63
|
Atenolol
|
10,675,235
|
Beta blocker
|
|
64
|
Glimepiride
|
10,407,351
|
Antidiabetic
|
|
65
|
Folic Acid
|
10,185,562
|
Vitamin
|
|
66
|
Zolpidem
|
9,972,232
|
Z-drug
|
|
67
|
Latanoprost
|
9,971,002
|
Prostaglandin analogue
|
|
68
|
Doxycycline
|
9,833,973
|
Antibiotic
|
|
69
|
Lisdexamfetamine
|
9,791,955
|
Psychostimulant
|
|
70
|
Insulin Lispro
|
9,647,313
|
Antidiabetic
|
|
71
|
Clonidine
|
9,626,080
|
Alpha-2 agonist
|
|
72
|
Loratadine
|
9,230,347
|
Antihistamine
|
|
73
|
Finasteride
|
9,203,008
|
5α-Reductase inhibitor
|
|
74
|
Dulaglutide
|
8,968,874
|
Antidiabetic
|
|
75
|
Hydrochlorothiazide; Losartan
|
8,825,878
|
Diuretic + angiotensin II receptor blocker
|
|
76
|
Insulin Aspart
|
8,813,259
|
Antidiabetic
|
|
77
|
Propranolol
|
8,810,846
|
Beta blocker
|
|
78
|
Azithromycin
|
8,770,185
|
Antibiotic
|
|
79
|
Ezetimibe
|
8,656,499
|
Lipid-lowering agent
|
|
80
|
Ethinyl Estradiol; Norethindrone
|
8,582,372
|
Synthetic hormone
|
|
81
|
Lorazepam
|
8,502,480
|
Benzodiazepine
|
|
82
|
Quetiapine
|
8,443,014
|
Antipsychotic
|
|
83
|
Budesonide; Formoterol
|
8,225,092
|
Glucocorticoid + LABA
|
|
84
|
Topiramate
|
8,210,654
|
Anticonvulsant
|
|
85
|
Warfarin
|
8,135,552
|
Anticoagulant
|
|
86
|
Sitagliptin
|
7,947,929
|
Antidiabetic
|
|
87
|
Amitriptyline
|
7,887,977
|
Antidepressant
|
|
88
|
Fenofibrate
|
7,816,415
|
Lipid-lowering agent
|
|
89
|
Naproxen
|
7,381,940
|
NSAID
|
|
90
|
Rivaroxaban
|
7,298,837
|
Anticoagulant
|
|
91
|
Pregabalin
|
7,167,540
|
Anticonvulsant
|
|
92
|
Paroxetine
|
7,127,748
|
Antidepressant
|
|
93
|
Celecoxib
|
7,023,511
|
NSAID
|
|
94
|
Tizanidine
|
6,971,104
|
Alpha-2 agonist
|
|
95
|
Sumatriptan
|
6,899,199
|
Antimigraine drug
|
|
96
|
Amoxicillin; Clavulanate
|
6,874,603
|
Antibiotic
|
|
97
|
Olmesartan
|
6,554,547
|
Angiotensin II receptor blocker
|
|
98
|
Acetaminophen; Oxycodone
|
6,531,255
|
Analgesic
|
|
99
|
Ethinyl Estradiol; Norgestimate
|
6,339,863
|
Synthetic hormone
|
|
100
|
Diltiazem
|
6,257,580
|
Calcium channel blocker
|
|
