Challenging Questions about Heredity 2 - Statistics

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In peas, yellow (Y) is dominant to green (y), and round (R) is dominant to wrinkled (r). What is the probability of producing a green, wrinkled offspring from a cross YyRr × Yyrr? 1/8
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A monohybrid cross is performed between two heterozygous individuals (Aa × Aa). Which Punnett square result correctly represents the expected genotypic ratio? 1 AA : 2 Aa : 1 aa
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If a DNA sample contains 20% adenine, what percentage of cytosine is expected? 30%
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In a dihybrid cross AaBb × AaBb, assuming independent assortment, what fraction of offspring are expected to be heterozygous for both traits? 4/16
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A cross produces 75% dominant phenotype and 25% recessive phenotype offspring. Which parental genotypes are most consistent with this data? Aa × Aa
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During which phase of mitosis do sister chromatids separate and move toward opposite poles? Anaphase
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What is the correct first step in preparing a human karyotype? Arresting cells in metaphase
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A trait appears in every generation and affects males and females equally. What is the most likely mode of inheritance? Autosomal dominant
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Which abnormality would most likely be detected using karyotype analysis? Chromosomal translocation
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Why are cells arrested in metaphase for karyotyping? Chromosomes are most condensed
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Chargaff’s rules support which structural feature of DNA? Complementary base pairing
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Which process increases genetic variation by exchanging genetic material between homologous chromosomes? Crossing over
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25. Which enzyme synthesizes new DNA strands during elongation? DNA polymerase
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How does metaphase I of meiosis differ from metaphase of mitosis? Homologous chromosomes line up as pairs
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A heterozygous individual shows an intermediate phenotype between two homozygotes. Which inheritance pattern best explains this observation, and which Mendelian law does it violate? Incomplete dominance; Law of Dominance
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Which structure attaches chromosomes to spindle fibers? Kinetochore
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Two genes located close together on the same chromosome are inherited together more often than expected. This phenomenon violates which Mendelian principle? Law of Independent Assortment
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A karyotype labeled 46,XY indicates: Male with normal chromosome number
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A cross involving recessive epistasis produces a phenotypic ratio of 9:3:4. What does this ratio indicate? One gene masking the expression of another
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DNA strands run antiparallel because: One strand runs 5′→3′ and the other 3′→5′
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Which components form the backbone of a DNA molecule? Phosphate and sugar
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Synapsis and crossing over occur during which stage of meiosis? Prophase I
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In Labrador retrievers, coat color is determined by two genes: B/b and E/e. Dogs with genotype ee are yellow regardless of B/b genotype. This is an example of: Recessive epistasis
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A karyotype showing three copies of chromosome 21 indicates: Trisomy 21
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A pedigree shows affected males, no affected females, and transmission from carrier mothers to sons. Which inheritance pattern fits best? X-linked recessive
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