Paper 2 references

Selective TDP-43 depletion in post mitotic motor neurons-- ALS like phenotype

Overexpression of TDP-43 caused clear aggregates and loss of upper and lower MNs

Discovered first clock gene- "per", since "per" null flies were arrhythmic, flies with missense mutations had altered circadian rhythms

Mice with double mPer1/ mPer2 KO have no intrinsic circadian rhythms

D1 optic stimulation - increased movement (direct pathway); D2 optic stimulation- decreased movement (Indirect pathway)

Decreased D2 receptor occupancy in people with schizophrenia

Confirmation of Schultz 1999 - mice sucrose reward (prediction-error model)

Mapped somatotopic hand area in S1 in individuals with syndactyly - showed shrunken, ill-defined cortical organisation

Auditory-evoked MEG responses to human voices in schizophrenia patients - showed significant auditory gating deficits

X-irradiated rats during main stage of oligodendrocyte proliferation - almost no staining for MBP and increased number of optic nerve fibres

Nogo-A KO mice; CST transections - increased labelled fibres found crossing the lesion indicating enhanced regen.

Nogo-A,B,C triple KO mice; dorsal hemisection of spinal cord - no significant difference in axon regen.

NgR mutant mice had no significant difference in regenerative response to spinal cord injury

OMgp -/- mice; complete spinal cord transections - increased labelled axons rostral to lesion although limited and no regen in CST

ephrinB3 -/- mice; CST fibres labelled following dorsal hemisection; after 6 weeks - large number of fibres entering lesion site (none in WT)