Paper 2 references - Statistics

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Answer Stats
Hint Author Date Methods % Correct
Decreased D2 receptor occupancy in people with schizophrenia Abi-Dargham 2000 SPECT
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Discovered first clock gene- "per", since "per" null flies were arrhythmic, flies with missense mutations had altered circadian rhythms Benzer 1971 Screened mutant drosophila (A further clock gene- "cry" was identified soon after with similar strategy).
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X-irradiated rats during main stage of oligodendrocyte proliferation - almost no staining for MBP and increased number of optic nerve fibres Colello 1994
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Confirmation of Schultz 1999 - mice sucrose reward (prediction-error model) Day 2007 Fast-scan voltammetry (FCV)
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ephrinB3 -/- mice; CST fibres labelled following dorsal hemisection; after 6 weeks - large number of fibres entering lesion site (none in WT) Duffy 2012
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Auditory-evoked MEG responses to human voices in schizophrenia patients - showed significant auditory gating deficits Hirano 2010
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OMgp -/- mice; complete spinal cord transections - increased labelled axons rostral to lesion although limited and no regen in CST Ji 2008
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D1 optic stimulation - increased movement (direct pathway); D2 optic stimulation- decreased movement (Indirect pathway) Kravitz 2010
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Nogo-A,B,C triple KO mice; dorsal hemisection of spinal cord - no significant difference in axon regen. Lee 2009 Anterograde labelling
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Mapped somatotopic hand area in S1 in individuals with syndactyly - showed shrunken, ill-defined cortical organisation Mogilner 1983
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Nogo-A KO mice; CST transections - increased labelled fibres found crossing the lesion indicating enhanced regen. Simonen 2003 Anterograde labelling
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Overexpression of TDP-43 caused clear aggregates and loss of upper and lower MNs Wils 2010
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Selective TDP-43 depletion in post mitotic motor neurons-- ALS like phenotype Wu 2012 One TDP-43 allele KOd, the other floxed; Cre recombinase expressed under HB9 promoter.
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Mice with double mPer1/ mPer2 KO have no intrinsic circadian rhythms Zheng 2010
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NgR mutant mice had no significant difference in regenerative response to spinal cord injury Zheng 2005
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