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Hint
Answer
Name for a disease in babies who are born with an infectious disease
Congenital
The ability of a pathogen to spread to adjacent tissues
Invasiveness
Sudden increase in frequency of disease above expected number
Epidemic
Vaccine containing purified antigen from pathogen
Acellular/Subunit
Period disease is most severe, signs and symptoms
Illness
What do some pathogens create which allows them to infect as an airbourne illness? (Examples :Bacillus anthracis, Clostridium species)
Spores
Which type of penetration by a pathogen would spread into skin lesions / wounds, insect / animal bites
Passive
What is the only human disease to be eradicated?
Smallpox
Which type of intracellular pathogens grow within or outside cells
Facultative
Involves scratching scab material from someone with a mild case of smallpox and using it to inoculate scratch in the skin to intentionally cause disease
Variolation
Physical interaction between source/reservoir and host, disease spreading person to person
Direct Contact
Period with onset of signs and symptoms not clear enough for diagnosis
Prodromal
A preparation of microbial antigens used to induce protective immunity
Vaccine
Stimulate T-cells to release cytokines and can trigger cytokine storm – multiple organ failure
Superantigens
Increase in disease occurrence within large population over wide region (usually worldwide)
Pandemic
Who invented the first vaccine?
Edward Jenner
Living organisms that transmit pathogens
Vector
Disease spreading via an infected intermediate, as opposed to person-person transmission
Indirect Contact
Vaccine response causing neutralising antibodies that inactivate extracellular pathogen
Humoral
Dose that kills 50% of experimental animals within a specified period
Lethal dose 50/LD50
Which type of penetration involves degrading complexes between cells and attacking the extracellular matrix?
Active
The degree or intensity of disease a pathogen can cause
Virulence
Hint
Answer
Heat stable components of the pathogen that exert effects in the host when the pathogen lyses or divides
Endotoxin
Vaccines containing mRNA
RNA
Period after pathogen entry, before signs and symptoms
Incubation
Disease that occurs occasionally and at irregular intervals
Sporadic
What state are you in if you are carrying a pathogen but showing no symptoms?
Carrier state
Period where signs and symptoms begin to disappear
Convalescence
Vaccines containing pathogens that can replicate but only weakly compared to wildtype
Live attenuated
Soluble, heat-labile, proteins that are secreted into surroundings as pathogen grows
Exotoxin
Disease that maintains a relatively steady low-level frequency at a moderately regular interval
Endemic
Vaccine containing entire pathogen inactivated e.g. with formaldehyde
Inactivated whole cell
Vaccine response which kills cells that have been infected with intracellular pathogen
Cellular
Sudden, unexpected occurrence of disease, usually focal or in a limited segment of population
Outbreak
When a disease is transmitted from animals to humans
Zoonosis
When a large enough proportion of the population has acquired immunity to a pathogen, susceptible individuals are protected due to reduced transmission
Herd Immunity
Science that evaluates occurrence, determinants, distribution, and control of health and disease in a defined human population
Epidemiology
Diseases which gradually increase in occurrence frequency above endemic level but not to epidemic level
Hyperendemic
The result obtained when vaccine stimulates immunity
Immunisation
Mixed with antigens in vaccines to enhance the rate and degree of immunization
Adjuvants
Number of pathogens that will infect 50% of an experimental group of hosts in a specified time
Infectious dose 50/ID50
The ability of a microbe to cause disease
Pathogenicity
Which type of intracellular pathogens only grow when inside cells