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MODA Cardiovascular and Renal Pharmacology Human Specific

Hypertension, Atherosclerosis, Angina, Dysrhythmia
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yeahbutyou
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Last updated: May 28, 2023
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First submittedMay 28, 2023
Times taken4
Average score36.1%
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Hint
 
Answer
Anti-hypertensives
Diuretic
Furosemide
 
ACE Inhibitor
Ramipril
 
beta blocker
Atenolol
 
Calcium Blocker
Verapamil
 
Potassium Channel Opener
Opens K-ATP
Hirsutism
Severe Refractory Hypertension
Minoxidil
 
Sulphonylurea
Glibenclamide
 
a2 antagonist (Gi --> ↓NT Release)
Clonidine
 
Imidazoline Receptor Agonist
I1R is central GPCR -> ↑DAG + ArachAcid
Moxonidine
 
False Transmitter, a2 agonist
aMethylDOPA
Atherosclerosis
HMG-CoA Reductase inhibitor
impairs cholesterol synth
↑LDL uptake in liver
Arvostatin
SREBP/SCAP Pathway
on what gene
INSIG
 
SCAP are
chaperones
 
Leaves ER to
Golgi
 
Cleaved twice to release a ___ type TF
bHLH
 
PCSK9 inhibitor
Prevents recyling of LDL
Familial Hypercholesterolaemia is LDLR mutation
Evolocumab
 
PCSK9 inhibitor (siRNA)
Inclisiran
 
Fibrate - ↑lipoprotein lipase to release TAGs from VLDL to be absorbed by muscles
Bezafibrate
Reverse Cholesterol Transport Pathway
PPAR Agonist
PPAR -> ↑Liver X Receptors -> ↑ABCA1 ->↑HDL
Pioglitazone
Hint
 
Answer
 
Bile reabsorption inhibitor
Cholestyramine
 
Inhibits intestinal cholesterol uptake (enterogepatic recirculation)
Ezetimibe
 
Inhibits citrate production (needed +CoA to make cholesteol)
Bempedoic Acid
 
Stops liver TAG production and VLDL secretion + anticoagulative
nicotinic acid
 
reduces hypertriglyceridaemia cia arachidonic acid replacement
fish oil
Angina
Collateral Vasodilator
Liver converts to mononitrate (induces NO production)
Glyceryl trinitrate
 
Non-collateral vasodilator (diverts blood way from ischaemic region)
Dipyridamole
 
beta antagonist
atenolol
 
calcium blocker
verapamil
 
Funny current blocker (via HCN)
Ivabradine
 
Late Na Current blocker, ↓NCX -> ↓Ca overload -> relaxation not impaired
Ranolazine
Reperfusion Injury
Ischaemia creates ROS and
AMP
 
AMP leads to activation of
PKC
 
which opens
K-ATP
 
Which opens ____ in the mitochondria (close in ischaemia to prevent damage)
MPTP
 
Treat with ATP preservation drug or by opening K-ATP channels
Nicorandil
 
also treat with bypass or
stents
Anti-dysrhythmics
Gi coupled -> increased K-ATP
Adenosine
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