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Hint
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Author
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Year
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Methods
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Specific cells fired maximally when mouse is in specific parts of the environment
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O'Keefe
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1971
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NMDAR-dependent LTP is required for associative spatial memory acquisition
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Morris
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1986
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Mice, NMDAR antagonists
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Spatial pre-training in another maze ameliorated effects of above experiment
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Bannerman
|
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1995
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Decreased performance in a Morris water maze when LTP could not be induced, due to hippocampus-selective GluN1 KO
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Tsien
|
|
1996
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|
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GluA1 -/- mice have large reductions in measures of spatial and directional selectivity
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Resnik
|
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2012
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Radial maze--> decreased peformance
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A peptide preventing AMPAR internalisation blocked LTD induction and led to deficits in object recognition in rats
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Griffiths
|
|
2008
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|
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Selective destruction of climbing fibres abolished NO responses
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Shibuki
|
|
1991
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NO probe
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Purkinje-specific PKG KO in mice led to inability to induce LTD and impaired VOR adaptation
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Feil
|
|
2003
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PKC inhibitor expressed under Purkinje-specific promoter in transgenic mice--> attenuated LTD, VOR adaptation impaired
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De Zeeuw
|
|
1998
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Attenuated LTD by perfusing Purkinje cells with peptides interfering with PICK1/GluR interactions
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Xia
|
|
2000
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|
|
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Transgenic mice models with AMPAR internalisation defects attenuated LTD, although normal basic motor functions and no impairment of VOR adaptation
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Schonewille
|
|
2011
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|
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10ms delay in somatic current injections could incur LTD or LTP depending on pairing (post-pre or pre-post)
|
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Markram
|
|
1997
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Somatic current injection into bidirectionally connected cells
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STDP in xenopus retinotectal synaptic circuit
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|
Zhang
|
|
1998
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|
|
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STDP can influence sensory receptive field
|
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Vislay-Meltzer
|
|
2006
|
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Mapped receptive fields of xenopus tectal neurons, flashes of light on retina paired with injection of somatic current
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|
Application of DA can convert LTD to LTP or reverse LTD depending on timing
|
|
Brzosko
|
|
2015
|
|
Schaffer-collateral CA1 pathway
|
|
STDP in the pre-post pairing of place cells
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Meha
|
|
1997
|
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Mice trained to run unidirectionally, specific cells fired in sequence
|
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STDP in inhibitory GABAergic synapses
|
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Woodin
|
|
2008
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|
|
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STDP in converging inhibitory and excitatory inputs
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D'amour
|
|
2015
|
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IPSCs/ EPSCs paired with postsynaptic APs respectively
|
|
Dendritic spikes are required for LTP
|
|
Remy
|
|
2007
|
|
TTX applied to soma, dendritic spikes recorded in neurons displaying LTP
|
|
No change in LTP when TTX applied to soma and axon
|
|
Hardie
|
|
2009
|
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Stratum radiatum
|
|
NMDAR blocker prevented LTP
|
|
Collingridge
|
|
1983
|
|
AP-5 applied in SC-CA1 pathway (rats)
|
|
EGTA (calcium chelator) blocked LTP
|
|
Lynch
|
|
1983
|
|
|
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Intracellular photolysis of calcium caging compound was enough to induce LTP
|
|
Malenka
|
|
1988
|
|
|
|
Inhibition of CaMKII prevents induction of LTP
|
|
Silva
|
|
1992
|
|
CaMKII inhibitory peptide, mice with loss-of-function CaMKII mutation
|
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Activation of postsynaptic CaMKII sufficient to induce LTP
|
|
Lledo
|
|
1995
|
|
Postsynaptic injection of preactivated CaMKII monomers
|
|
CaMKII not required for LTP maintenance
|
|
Malinow
|
|
1989
|
|
CaMKII inhibitor added after induction of LTP
|
|
Atypic PKC inhibitor returned EPSP to baseline after LTP induction
|
|
Ling
|
|
2005
|
|
|
|
PKMzeta KO mice had normal LTP
|
|
Volk
|
|
2013
|
|
|
|
LTP increases transmitter release
|
|
Zakharenko
|
|
2003
|
|
FM1-43 dye (becomes fluorescent when integrated with membrane phospholipids
|
|
Calcium transients increased significantly after LTP induction
|
|
Emptage
|
|
2003
|
|
Calcium transients as indicators of release probability
|
|
When GluR1 AMPARs coexpressed with CaMKII, increased conductance
|
|
Derkrach
|
|
1999
|
|
Patch-clamp recordings
|
|
Isolated NMDAR-only cells; found AMPAR-EPSCs after LTP induction
|
|
Isaac
|
|
1995
|
|
|
|
AMPARs seen redistributed to dendritic spine surfaces
|
|
Shi
|
|
1999
|
|
GluR-1-GFP, electron microscopy
|
|
Most SC-CA1 have coexpression of NMDAR and AMPAR
|
|
Racca
|
|
2010
|
|
Immunogold NMDAR/AMPAR labelling
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